Seroatlas · Human Serome Atlas

CA6

Carbonic anhydrase 6

Also known as: CAH6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23280
Gene
CA6
Ensembl
ENSG00000131686
Chromosome
1
Canonical length
308 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>P23280|CA6
     1  MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI NLQRTKVRYN
    61  PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA DGTVYIAQQM HFHWGGASSE
   121  ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD IAQDAPDGLA VLAAFVEVKN YPENTYYSNF
   181  ISHLANIKYP GQRTTLTGLD VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS
   241  RTQVWKLENS LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL
   301  DYLRRALN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
8,840 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 8,840 nTPM
  • skin: 30 nTPM
  • breast: 19 nTPM
  • pancreas: 5.9 nTPM
  • epididymis: 2.1 nTPM
  • bone marrow: 1.9 nTPM

Single-cell type

  • salivary acinar cells: 4,590 nCPM
  • salivary myoepithelial cells: 1,428 nCPM
  • breast lactating cells: 758 nCPM
  • neutrophils: 210 nCPM
  • salivary basal cells: 41 nCPM
  • breast secretory cells: 38 nCPM

Immune cell

  • naive CD8 T-cell: 17 nTPM
  • naive CD4 T-cell: 5.7 nTPM
  • memory CD8 T-cell: 2.7 nTPM
  • total PBMC: 1.6 nTPM
  • basophil: 1.4 nTPM
  • neutrophil: 1.4 nTPM

Brain region

  • white matter: 7.6 nTPM
  • cerebellum: 6.2 nTPM
  • medulla oblongata: 6.1 nTPM
  • cerebral cortex: 5.8 nTPM
  • pons: 5.8 nTPM
  • thalamus: 5.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CA6.

Disease | AutoantibodyPubMed

Conditions in which antibodies against CA6 are reported. Each links to that disease's full target list.

Showing 1 of 2 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for CA6 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

7 publications

Show 2 more

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CA6 as an antibody target. Whether an autoantibody or antibody against CA6 could matter depends on whether native CA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CA6 is annotated as secreted, so native CA6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CA6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...