Membrane associated eicosanoid/glutathione metabolism-like domain superfamily

Definition

This domain is found in a widespread superfamily known as MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) PMID:10091672. Included in this superfamily are: 5-lipoxygenase activating protein (gene FLAP), which seems to be required for the activation of 5-lipoxygenase. Leukotriene C4 synthase ([ec:2.5.1.37]), which catalyses the production of LTC4 from LTA4. Microsomal glutathione S-transferase II ([ec:2.5.1.18]) (GST-II), which also produces LTC4 from LTA4. Prostaglandin E synthase, which catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). The structure of this domain consists of four transmembrane helices PMID:17600184.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• ALOX5AP
• LTC4S
• MGST1
• MGST2
• MGST3
• PTGES