Seroatlas · Human Serome Atlas

LTC4S

Leukotriene C4 synthase

Also known as: LTC4S_HUMAN, MGC33147

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16873
Gene
LTC4S
Ensembl
ENSG00000213316
Chromosome
5
Canonical length
150 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>Q16873|LTC4S
     1  MKDEVALLAA VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERVY RAQVNCSEYF
    61  PLFLATLWVA GIFFHEGAAA LCGLVYLFAR LRYFQGYARS AQLRLAPLYA SARALWLLVA
   121  LAALGLLAHF LPAALRAALL GRLRTLLPWA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTC4S can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 12 nTPM
  • heart muscle: 11 nTPM
  • blood vessel: 9.9 nTPM
  • adipose tissue: 7.2 nTPM
  • lung: 6.7 nTPM
  • adrenal gland: 6.3 nTPM

Single-cell type

  • mast cells: 285 nCPM
  • microglia: 165 nCPM
  • fallopian secretory cells: 77 nCPM
  • hofbauer cells: 71 nCPM
  • megakaryocytes: 62 nCPM
  • hepatic stellate cells: 52 nCPM

Immune cell

  • eosinophil: 63 nTPM
  • basophil: 20 nTPM
  • myeloid DC: 8.6 nTPM
  • NK-cell: 4.7 nTPM
  • MAIT T-cell: 3 nTPM
  • memory CD4 T-cell: 2.1 nTPM

Brain region

  • white matter: 11 nTPM
  • spinal cord: 6.8 nTPM
  • thalamus: 6 nTPM
  • medulla oblongata: 5 nTPM
  • midbrain: 3.8 nTPM
  • cerebellum: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LTC4S in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTC4S as an antibody target. Whether an autoantibody or antibody against LTC4S could matter depends on whether native LTC4S is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTC4S is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LTC4S as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LTC4S. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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