Seroatlas · Human Serome Atlas

MGST3

Glutathione S-transferase 3, mitochondrial

Also known as: GST-III, MGST3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14880
Gene: MGST3
Ensembl: ENSG00000143198
Chromosome: 1
Canonical length: 152 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>O14880|MGST3
     1  MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN GHIFNCIQRA
    61  HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY AYGYYTGEPS KRSRGALGSI
   121  ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC CH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGST3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 721 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 721 nTPM
tongue: 540 nTPM
skeletal muscle: 533 nTPM
epididymis: 490 nTPM
duodenum: 337 nTPM
amygdala: 336 nTPM

Single-cell type

syncytiotrophoblasts: 2,677 nCPM
cytotrophoblasts: 2,622 nCPM
extravillous trophoblasts: 1,727 nCPM
epididymal principal cells: 1,621 nCPM
migrating cytotrophoblasts: 1,617 nCPM
enterocytes: 945 nCPM

Immune cell

non-classical monocyte: 196 nTPM
total PBMC: 185 nTPM
classical monocyte: 173 nTPM
intermediate monocyte: 151 nTPM
myeloid DC: 138 nTPM
memory CD4 T-cell: 131 nTPM

Brain region

hypothalamus: 237 nTPM
pons: 215 nTPM
cerebellum: 210 nTPM
white matter: 200 nTPM
medulla oblongata: 199 nTPM
cerebral cortex: 183 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MGST3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TFAM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGST3 as an antibody target. Whether an autoantibody or antibody against MGST3 could matter depends on whether native MGST3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGST3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MGST3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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