Seroatlas · Human Serome Atlas

MGST2

Microsomal glutathione S-transferase 2

Also known as: MGST-II, MGST2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99735
Gene
MGST2
Ensembl
ENSG00000085871
Chromosome
4
Canonical length
147 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q99735|MGST2
     1  MAGNSILLAA VSILSACQQS YFALQVGKAR LKYKVTPPAV TGSPEFERVF RAQQNCVEFY
    61  PIFIITLWMA GWYFNQVFAT CLGLVYIYGR HLYFWGYSEA AKKRITGFRL SLGILALLTL
   121  LGALGIANSF LDEYLDLNIA KKLRRQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MGST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
367 nTPM

Expression across tissuesHPA

Tissue

  • liver: 367 nTPM
  • esophagus: 184 nTPM
  • small intestine: 135 nTPM
  • duodenum: 125 nTPM
  • rectum: 114 nTPM
  • heart muscle: 112 nTPM

Single-cell type

  • esophageal apical cells: 1,055 nCPM
  • esophageal suprabasal cells: 848 nCPM
  • gastric progenitor cells: 775 nCPM
  • hofbauer cells: 692 nCPM
  • hepatocytes: 513 nCPM
  • breast lactating cells: 491 nCPM

Immune cell

  • plasmacytoid DC: 195 nTPM
  • myeloid DC: 147 nTPM
  • classical monocyte: 104 nTPM
  • intermediate monocyte: 65 nTPM
  • basophil: 44 nTPM
  • total PBMC: 40 nTPM

Brain region

  • choroid plexus: 39 nTPM
  • white matter: 27 nTPM
  • medulla oblongata: 22 nTPM
  • spinal cord: 22 nTPM
  • pons: 21 nTPM
  • hypothalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MGST2.

Disease | ImmuneIEDB

Conditions an epitope on MGST2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.08
gnomAD missense Z
0.37
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MGST2 as an antibody target. Whether an autoantibody or antibody against MGST2 could matter depends on whether native MGST2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MGST2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MGST2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MGST2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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