Carboxylesterase type B, active site

Definition

Higher eukaryotes have many distinct esterases. Among the different types are those which act on carboxylic esters ([ec:3.1.1]). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates [[cite:PMID:3163407], [cite:PMID:1862088], [cite:PMID:8453375]] that the majority are evolutionary related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This entry represents a conserved sequence containing the active site serine.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• ACHE
• BCHE
• CEL
• CES1
• CES2
• CES3
• CES4A
• CES5A