Seroatlas · Human Serome Atlas

CES4A

Carboxylesterase 4A

Also known as: CES8, EST4A_HUMAN, FLJ37464

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5XG92
Gene: CES4A
Ensembl: ENSG00000172824
Chromosome: 16
Canonical length: 561 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>Q5XG92|CES4A
     1  MRWILCWSLT LCLMAQTALG ALHTKRPQVV TKYGTLQGKQ MHVGKTPIQV FLGVPFSRPP
    61  LGILRFAPPE PPEPWKGIRD ATTYPPGCLQ ESWGQLASMY VSTRERYKWL RFSEDCLYLN
   121  VYAPARAPGD PQLPVMVWFP GGAFIVGAAS SYEGSDLAAR EKVVLVFLQH RLGIFGFLST
   181  DDSHARGNWG LLDQMAALRW VQENIAAFGG DPGNVTLFGQ SAGAMSISGL MMSPLASGLF
   241  HRAISQSGTA LFRLFITSNP LKVAKKVAHL AGCNHNSTQI LVNCLRALSG TKVMRVSNKM
   301  RFLQLNFQRD PEEIIWSMSP VVDGVVIPDD PLVLLTQGKV SSVPYLLGVN NLEFNWLLPY
   361  IMKFPLNRQA MRKETITKML WSTRTLLNIT KEQVPLVVEE YLDNVNEHDW KMLRNRMMDI
   421  VQDATFVYAT LQTAHYHRDA GLPVYLYEFE HHARGIIVKP RTDGADHGDE MYFLFGGPFA
   481  TGLSMGKEKA LSLQMMKYWA NFARTGNPND GNLPCWPRYN KDEKYLQLDF TTRVGMKLKE
   541  KKMAFWMSLY QSQRPEKQRQ F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CES4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 17 nTPM
skin: 13 nTPM
liver: 8.9 nTPM
cerebellum: 8.6 nTPM
pituitary gland: 7.7 nTPM
skeletal muscle: 5.3 nTPM

Single-cell type

breast lactating cells: 617 nCPM
thymic myoid cells: 211 nCPM
epididymal efferent duct ciliated cells: 184 nCPM
fallopian tube ciliated cells: 138 nCPM
respiratory ciliated cells: 95 nCPM
brain excitatory neurons: 66 nCPM

Immune cell

non-classical monocyte: 3.6 nTPM
intermediate monocyte: 2.5 nTPM
classical monocyte: 1.4 nTPM
plasmacytoid DC: 1.3 nTPM
memory CD4 T-cell: 1 nTPM
naive CD4 T-cell: 0.9 nTPM

Brain region

white matter: 35 nTPM
cerebral cortex: 21 nTPM
basal ganglia: 18 nTPM
hippocampal formation: 16 nTPM
medulla oblongata: 16 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.08
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carboxylic ester hydrolase activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CES4A as an antibody target. Whether an autoantibody or antibody against CES4A could matter depends on whether native CES4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CES4A is annotated as secreted, so native CES4A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CES4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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