Seroatlas · Human Serome Atlas

CES2

Cocaine esterase

Also known as: CE-2, CES2A1, EST2_HUMAN, iCE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00748
Gene
CES2
Ensembl
ENSG00000172831
Chromosome
16
Canonical length
559 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>O00748|CES2
     1  MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG
    61  IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS
   121  EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG
   181  VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS
   241  PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI
   301  LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ
   361  KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA
   421  LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE
   481  EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK
   541  ALPQKIQELE EPEERHTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CES2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
662 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 662 nTPM
  • small intestine: 543 nTPM
  • liver: 323 nTPM
  • colon: 179 nTPM
  • rectum: 168 nTPM
  • esophagus: 162 nTPM

Single-cell type

  • enterocytes: 571 nCPM
  • colonocytes: 119 nCPM
  • esophageal apical cells: 112 nCPM
  • enteric transient amplifying cells: 86 nCPM
  • hepatocytes: 79 nCPM
  • esophageal suprabasal cells: 66 nCPM

Immune cell

  • memory CD8 T-cell: 5.8 nTPM
  • classical monocyte: 5.4 nTPM
  • gdT-cell: 5.1 nTPM
  • naive CD4 T-cell: 4.8 nTPM
  • naive CD8 T-cell: 4.6 nTPM
  • MAIT T-cell: 4.5 nTPM

Brain region

  • choroid plexus: 36 nTPM
  • cerebellum: 32 nTPM
  • cerebral cortex: 30 nTPM
  • hippocampal formation: 28 nTPM
  • thalamus: 26 nTPM
  • amygdala: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CES2 as an antibody target. Whether an autoantibody or antibody against CES2 could matter depends on whether native CES2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CES2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CES2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CES2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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