Seroatlas · Human Serome Atlas

CES5A

Carboxylesterase 5A

Also known as: CAUXIN, CES4C1, CES5, CES7, EST5A_HUMAN, FLJ31547

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NT32
Gene: CES5A
Ensembl: ENSG00000159398
Chromosome: 16
Canonical length: 575 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q6NT32|CES5A
     1  MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS PVPVNVFLGV
    61  PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW LLLDQHMLKV HYPKFGVSED
   121  CLYLNIYAPA HADTGSKLPV LVWFPGGAFK TGSASIFDGS ALAAYEDVLV VVVQYRLGIF
   181  GFFTTWDQHA PGNWAFKDQV AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM
   241  AKGLFHKAIM ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL
   301  LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL PMKEAPEILS
   361  GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR DSLLDLLGDV FFVVPALITA
   421  RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV KADHADEVRF VFGGAFLKGD IVMFEGATEE
   481  EKLLSRKMMK YWATFARTGN PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR LKEPRVDFWT
   541  STIPLILSAS DMLHSPLSSL TFLSLLQPFF FFCAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CES5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

epididymis: 64 nTPM
liver: 3.7 nTPM
spinal cord: 0.9 nTPM
salivary gland: 0.7 nTPM
gallbladder: 0.6 nTPM
midbrain: 0.6 nTPM

Single-cell type

epididymal principal cells: 30 nCPM
renal collecting duct principal cells: 4.9 nCPM
oligodendrocytes: 2.4 nCPM
other brain neurons: 2 nCPM
brain inhibitory neurons: 1.5 nCPM
brain excitatory neurons: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1 nTPM
medulla oblongata: 0.6 nTPM
white matter: 0.6 nTPM
midbrain: 0.5 nTPM
basal ganglia: 0.4 nTPM
cerebellum: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carboxylesterase activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CES5A as an antibody target. Whether an autoantibody or antibody against CES5A could matter depends on whether native CES5A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CES5A is annotated as secreted, so native CES5A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CES5A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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