CEL

Protein identityUniProt · HPA

UniProt accession

P19835

Gene

CEL

Ensembl

ENSG00000170835

Chromosome

9

Canonical length

753 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted secreted proteins

Secretome location

Secreted to digestive system

OverviewNCBI Gene

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

753 residues, UniProt reviewed canonical sequence.

>P19835|CEL
     1  MGRLQLVVLG LTCCWAVASA AKLGAVYTEG GFVEGVNKKL GLLGDSVDIF KGIPFAAPTK
    61  ALENPQPHPG WQGTLKAKNF KKRCLQATIT QDSTYGDEDC LYLNIWVPQG RKQVSRDLPV
   121  MIWIYGGAFL MGSGHGANFL NNYLYDGEEI ATRGNVIVVT FNYRVGPLGF LSTGDANLPG
   181  NYGLRDQHMA IAWVKRNIAA FGGDPNNITL FGESAGGASV SLQTLSPYNK GLIRRAISQS
   241  GVALSPWVIQ KNPLFWAKKV AEKVGCPVGD AARMAQCLKV TDPRALTLAY KVPLAGLEYP
   301  MLHYVGFVPV IDGDFIPADP INLYANAADI DYIAGTNNMD GHIFASIDMP AINKGNKKVT
   361  EEDFYKLVSE FTITKGLRGA KTTFDVYTES WAQDPSQENK KKTVVDFETD VLFLVPTEIA
   421  LAQHRANAKS AKTYAYLFSH PSRMPVYPKW VGADHADDIQ YVFGKPFATP TGYRPQDRTV
   481  SKAMIAYWTN FAKTGDPNMG DSAVPTHWEP YTTENSGYLE ITKKMGSSSM KRSLRTNFLR
   541  YWTLTYLALP TVTDQEATPV PPTGDSEATP VPPTGDSETA PVPPTGDSGA PPVPPTGDSG
   601  APPVPPTGDS GAPPVPPTGD SGAPPVPPTG DSGAPPVPPT GDSGAPPVPP TGDSGAPPVP
   661  PTGDSGAPPV PPTGDAGPPP VPPTGDSGAP PVPPTGDSGA PPVTPTGDSE TAPVPPTGDS
   721  GAPPVPPTGD SEAAPVPPTD DSKEAQMPAV IRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

104,265 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEL.

Disease | AllUniProt

Conditions CEL is implicated in, by any mechanism.

• Maturity-onset diabetes of the young 8 with exocrine dysfunction (MODY8) MIM:609812

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 422 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Maturity-onset diabetes of the young type 8

ReferencesPubMed · IEDB

Publications for CEL from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.89

gnomAD pLI

0

gnomAD missense Z

0.11

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ceramide catabolic process
• intestinal cholesterol absorption
• lipid metabolic process
• pancreatic juice secretion

Molecular functions

• acetylesterase activity
• catalytic activity
• heparin binding
• hydrolase activity
• retinyl-palmitate esterase activity
• sterol ester esterase activity
• triacylglycerol lipase activity

Cellular components

• cytoplasm
• extracellular exosome
• extracellular region
• extracellular space
• membrane

Protein domainsUniProt · Pfam · InterPro

• Carboxylesterase, type B
• Carboxylesterase type B, conserved site
• Carboxylesterase type B, active site
• Alpha/Beta hydrolase fold
• Neuroligin and Bile salt-activated lipase
• Carboxylesterase family
• Mucin-like domain
• Mucin-like

KeywordsUniProt

• Diabetes mellitus
• Disulfide bond
• Glycoprotein
• Hydrolase
• Lipid degradation
• Lipid metabolism
• Repeat
• Secreted
• Serine esterase
• Signal

InteractionsUniProt · HPA

Protein binding partners of CEL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CLC