Allergen V5/Tpx-1-related, conserved site
IPR018244
Definition
The cysteine-rich secretory proteins (Crisp) are predominantly found in the mammalian male reproductive tract as well as in the venom of reptiles. This family includes mammalian testis-specific protein (Tpx-1), also known as cysteine-rich secretory protein 2 (CRISP2) PMID:2613236; venom allergen 5 from vespid wasps and venom allergen 3 from fire ants, which are potent allergens that mediate allergic reactions to stings insects of the Hymenoptera family PMID:8454859; scoloptoxins from Scolopendra dehaani (Thai centipede) PMID:23148443; plant pathogenesis proteins of the PR-1 family PMID:2026137, which are synthesised during pathogen infection or other stress-related responses; allurin, a sperm chemoattractant PMID:18342304, serotriflin PMID:18222185, etc. The precise function of some of these proteins is still unclear. Tpx-1 or CRISP2 may regulate some ion channels' activity and thereby regulate calcium fluxes during sperm capacitation PMID:16339766. This entry also includes allergen Tab y 5.0101 from horsefly salivary glands PMID:20608917.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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