Seroatlas · Human Serome Atlas

GLIPR1L1

GLIPR1-like protein 1

Also known as: GPRL1_HUMAN, MGC26856

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWM5
Gene
GLIPR1L1
Ensembl
ENSG00000173401
Chromosome
12
Canonical length
242 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable molecular adaptor activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization and protein localization involved in acrosome reaction. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in acrosomal vesicle and sperm head-tail coupling apparatus. Predicted to be part of protein complex involved in cell-cell adhesion. Predicted to be active in extracellular space and outer acrosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q6UWM5|GLIPR1L1
     1  MALKNKFSCL WILGLCLVAT TSSKIPSITD PHFIDNCIEA HNEWRGKVNP PAADMKYMIW
    61  DKGLAKMAKA WANQCKFEHN DCLDKSYKCY AAFEYVGENI WLGGIKSFTP RHAITAWYNE
   121  TQFYDFDSLS CSRVCGHYTQ LVWANSFYVG CAVAMCPNLG GASTAIFVCN YGPAGNFANM
   181  PPYVRGESCS LCSKEEKCVK NLCRTPQLII PNQNPFLKPT GRAPQQTAFN PFSLGFLLLR
   241  IF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLIPR1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • testis: 29 nTPM
  • skin: 0.5 nTPM
  • adrenal gland: 0.4 nTPM
  • cerebellum: 0.3 nTPM
  • endometrium: 0.3 nTPM
  • heart muscle: 0.3 nTPM

Single-cell type

  • late primary spermatocytes: 503 nCPM
  • cardiomyocytes: 316 nCPM
  • early spermatids: 221 nCPM
  • adipocytes: 113 nCPM
  • fibro-adipogenic progenitors: 82 nCPM
  • epicardial cells: 68 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 5.6 nTPM
  • basal ganglia: 4.6 nTPM
  • white matter: 4.6 nTPM
  • midbrain: 4.4 nTPM
  • hypothalamus: 4.2 nTPM
  • medulla oblongata: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GLIPR1L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLIPR1L1 as an antibody target. Whether an autoantibody or antibody against GLIPR1L1 could matter depends on whether native GLIPR1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLIPR1L1 is annotated at the cell surface, where native GLIPR1L1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GLIPR1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLIPR1L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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