CRISP3

Protein identityUniProt · HPA

UniProt accession

P54108

Gene

CRISP3

Ensembl

ENSG00000096006

Chromosome

6

Canonical length

245 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>P54108|CRISP3
     1  MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR EIVNKHNELR RAVSPPARNM
    61  LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL YMSSASSSWS QAIQSWFDEY
   121  NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR
   181  LYVPYEQGAP CASCPDNCDD GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC
   241  SNSIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRISP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

2,264 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.11

gnomAD pLI

0

gnomAD missense Z

-0.38

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response
• innate immune response

Cellular components

• extracellular matrix
• extracellular region
• extracellular space
• specific granule
• specific granule lumen
• tertiary granule lumen

Protein domainsUniProt · Pfam · InterPro

• Cysteine-rich secretory protein-related
• ShKT domain
• Cysteine-rich secretory protein
• CAP domain
• Allergen V5/Tpx-1-related, conserved site
• Cysteine-rich secretory protein, SCP domain
• CAP superfamily
• Crisp-like domain
• Cysteine-rich secretory protein family
• Crisp

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of CRISP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• A1BG