Seroatlas · Human Serome Atlas

CRISP2

Cysteine-rich secretory protein 2

Also known as: CRIS2_HUMAN, CRISP-2, CT36, GAPDL5, TPX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P16562
Gene: CRISP2
Ensembl: ENSG00000124490
Chromosome: 6
Canonical length: 243 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be involved in sexual reproduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>P16562|CRISP2
     1  MALLPVLFLV TVLLPSLPAE GKDPAFTALL TTQLQVQREI VNKHNELRKA VSPPASNMLK
    61  MEWSREVTTN AQRWANKCTL QHSDPEDRKT STRCGENLYM SSDPTSWSSA IQSWYDEILD
   121  FVYGVGPKSP NAVVGHYTQL VWYSTYQVGC GIAYCPNQDS LKYYYVCQYC PAGNNMNRKN
   181  TPYQQGTPCA GCPDDCDKGL CTNSCQYQDL LSNCDSLKNT AGCEHELLKE KCKATCLCEN
   241  KIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRISP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 482 nTPM

Expression across tissuesHPA

Tissue

testis: 482 nTPM
fallopian tube: 23 nTPM
bone marrow: 16 nTPM
salivary gland: 16 nTPM
gallbladder: 7.3 nTPM
choroid plexus: 4 nTPM

Single-cell type

late spermatids: 40,585 nCPM
early spermatids: 6,298 nCPM
late primary spermatocytes: 2,271 nCPM
leydig cells: 60 nCPM
respiratory ciliated cells: 59 nCPM
sertoli cells: 44 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.5 nTPM
hypothalamus: 0.4 nTPM
medulla oblongata: 0.2 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRISP2 as an antibody target. Whether an autoantibody or antibody against CRISP2 could matter depends on whether native CRISP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRISP2 is annotated as secreted, so native CRISP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CRISP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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