Seroatlas · Human Serome Atlas

GLIPR1

Glioma pathogenesis-related protein 1

Also known as: GLIP1_HUMAN, GliPR, RTVP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48060
Gene
GLIPR1
Ensembl
ENSG00000139278
Chromosome
12
Canonical length
266 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>P48060|GLIPR1
     1  MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP TASDMLYMTW
    61  DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI WTGSVPIFSV SSAITNWYDE
   121  IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG CAVQFCPKVS GFDALSNGAH FICNYGPGGN
   181  YPTWPYKRGA TCSACPNNDK CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV
   241  NSVILILSVI ITILVQHKYP NLVLLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLIPR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 81 nTPM
  • appendix: 44 nTPM
  • smooth muscle: 37 nTPM
  • spleen: 34 nTPM
  • urinary bladder: 33 nTPM
  • gallbladder: 31 nTPM

Single-cell type

  • extravillous trophoblasts: 658 nCPM
  • monocytes: 390 nCPM
  • neutrophils: 336 nCPM
  • cdc: 295 nCPM
  • hofbauer cells: 270 nCPM
  • kupffer cells: 266 nCPM

Immune cell

  • neutrophil: 465 nTPM
  • classical monocyte: 354 nTPM
  • non-classical monocyte: 267 nTPM
  • total PBMC: 265 nTPM
  • myeloid DC: 241 nTPM
  • intermediate monocyte: 233 nTPM

Brain region

  • white matter: 22 nTPM
  • cerebral cortex: 15 nTPM
  • thalamus: 13 nTPM
  • medulla oblongata: 12 nTPM
  • choroid plexus: 12 nTPM
  • pons: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GLIPR1.

Disease | ImmuneIEDB

Conditions an epitope on GLIPR1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.75
gnomAD pLI
0
gnomAD missense Z
0.18
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLIPR1 as an antibody target. Whether an autoantibody or antibody against GLIPR1 could matter depends on whether native GLIPR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLIPR1 is annotated at the cell surface, where native GLIPR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GLIPR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLIPR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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