Seroatlas · Human Serome Atlas

CRISPLD1

Cysteine-rich secretory protein LCCL domain-containing 1

Also known as: Cocoacrisp, CRLD1_HUMAN, DKFZp762F133, LCRISP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H336
Gene
CRISPLD1
Ensembl
ENSG00000121005
Chromosome
8
Canonical length
500 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Involved in face morphogenesis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q9H336|CRISPLD1
     1  MKCTAREWLR VTTVLFMARA IPAMVVPNAT LLEKLLEKYM DEDGEWWIAK QRGKRAITDN
    61  DMQSILDLHN KLRSQVYPTA SNMEYMTWDV ELERSAESWA ESCLWEHGPA SLLPSIGQNL
   121  GAHWGRYRPP TFHVQSWYDE VKDFSYPYEH ECNPYCPFRC SGPVCTHYTQ VVWATSNRIG
   181  CAINLCHNMN IWGQIWPKAV YLVCNYSPKG NWWGHAPYKH GRPCSACPPS FGGGCRENLC
   241  YKEGSDRYYP PREEETNEIE RQQSQVHDTH VRTRSDDSSR NEVISAQQMS QIVSCEVRLR
   301  DQCKGTTCNR YECPAGCLDS KAKVIGSVHY EMQSSICRAA IHYGIIDNDG GWVDITRQGR
   361  KHYFIKSNRN GIQTIGKYQS ANSFTVSKVT VQAVTCETTV EQLCPFHKPA SHCPRVYCPR
   421  NCMQANPHYA RVIGTRVYSD LSSICRAAVH AGVVRNHGGY VDVMPVDKRK TYIASFQNGI
   481  FSESLQNPPG GKAFRVFAVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRISPLD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 66 nTPM
  • breast: 27 nTPM
  • prostate: 23 nTPM
  • parathyroid gland: 18 nTPM
  • salivary gland: 18 nTPM
  • ovary: 14 nTPM

Single-cell type

  • prostatic glandular cells: 353 nCPM
  • endometrial ciliated cells: 352 nCPM
  • ependymal cells: 227 nCPM
  • epididymal efferent duct ciliated cells: 147 nCPM
  • breast myoepithelial cells: 116 nCPM
  • oligodendrocyte progenitor cells: 83 nCPM

Immune cell

  • plasmacytoid DC: 0.7 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 23 nTPM
  • midbrain: 23 nTPM
  • medulla oblongata: 19 nTPM
  • hypothalamus: 18 nTPM
  • spinal cord: 14 nTPM
  • hippocampal formation: 9.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CRISPLD1.

Disease | ImmuneIEDB

Conditions an epitope on CRISPLD1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRISPLD1 as an antibody target. Whether an autoantibody or antibody against CRISPLD1 could matter depends on whether native CRISPLD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRISPLD1 is annotated as secreted, so native CRISPLD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CRISPLD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRISPLD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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