Integrase-like, N-terminal

Definition

This entry represents a structural domain with an α-helical, orthogonal bundle fold. Domains with this structure are found at the N-terminal (zinc-binding domain) of HIV integrase, and in the following hypothetical proteins: YebC from Escherichia coli, HP0162 from Helicobacter pylori (Campylobacter pylori) and aq1575 from Aquifex aeolicus PMID:12060744. Retroviral integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains: an N-terminal zinc binding domain, a central catalytic core and a C-terminal DNA-binding domain [[cite:PMID:11743009], [cite:PMID:11101216]]. It is often found as part of the POL polyprotein.

10 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (10 proteins: gene, accession, name)

• ERVK-10
• ERVK-11
• ERVK-18
• ERVK-19
• ERVK-25
• ERVK-6
• ERVK-7
• ERVK-8
• HERVK_113
• TACO1