E2F Family

Definition

The E2F family of transcription factors plays a crucial role in the control of cell cycle [[cite:PMID:22903062], [cite:PMID:20040599]] and action of tumour suppressor proteins. This family consists of eight members and is divided into activators (E2F1-3) and repressors (E2F4-8) depending on cellular context, target gene and cofactors PMID:22903062. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA-binding domain, a dimerisation domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumour suppressor protein association domain which is embedded within the transactivation domain PMID:7739537. Classical E2Fs (E2F1-6) contain one DNA-binding domain which form heterodimers with DP proteins; atypical family members, E2F7 and E2F8, possess two DNA-binding domains, form homodimers or heterodimers, thus regulating transcription in a DP-independent manner PMID:22903062.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• E2F1
• E2F2
• E2F3
• E2F4
• E2F5
• E2F6
• E2F7
• E2F8