Seroatlas · Human Serome Atlas

TUBB8B

Tubulin beta 8B

Also known as: TBB8B_HUMAN, TUBB8P12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNZ2
Gene: TUBB8B
Ensembl: ENSG00000173213
Chromosome: 18
Canonical length: 444 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body,Flagellar centriole,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in intercellular bridge; microtubule; and mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>A6NNZ2|TUBB8B
     1  MREIVLTQTG QCGNQIGAKF WEVISDEHAI DSAGTYHGDS HLQLERINVH HHEASGGRYV
    61  PRAVLVDLEP GTMDSVHSGP FGQVFRPDNF ISGQCGAGNN WAKGRYTEGA ELTESVMDVV
   121  RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIINTFSIL PSPKVSDTVV
   181  EPYNATLSVH QLIENADETF CIDNEALYDI CSRTLKLPTP TYGDLNHLVS ATMSGVTTCL
   241  RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVAELT QQMFDAKNMM
   301  AACDPRHGCY LTVAAIFRGR MPMREVDEQM FNIQDKNSSY FADWFPDNVK TAVCDIPPRG
   361  LKMSATFIGN NAAIQELFTC VSEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
   421  EYQQYQDATA EEEEDEEYAE EEVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBB8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 4.3 nTPM

Expression across tissuesHPA

Tissue

testis: 4.3 nTPM
ovary: 1.5 nTPM
pituitary gland: 0.4 nTPM
esophagus: 0.2 nTPM
kidney: 0.2 nTPM
small intestine: 0.2 nTPM

Single-cell type

oocytes: 161 nCPM
early primary spermatocytes: 47 nCPM
differentiating spermatogonia: 40 nCPM
late primary spermatocytes: 7.3 nCPM
undifferentiated spermatogonia: 6 nCPM
early spermatids: 3.7 nCPM

Immune cell

intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBB8B.

Disease | ImmuneIEDB

Conditions an epitope on TUBB8B was assayed in.

Chagas disease B cell

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBB8B as an antibody target. Whether an autoantibody or antibody against TUBB8B could matter depends on whether native TUBB8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBB8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBB8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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