SLC26A/SulP transporter domain
IPR011547
Definition
This entry represents a conserved domain found in a group of sulphate transporters, known as the SLC26A/SulP family [[cite:PMID:8140616], [cite:PMID:7616962]]. These proteins contain an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain a STAS (sulfate transporter and anti-sigma factor antagonist) domain PMID:10662676. This central domain is usually found next to the STAS domain ([interpro:IPR002645]). Proteins containing this domain include: Neurospora crassa sulphate permease II (gene cys-14). Yeast sulphate permeases (genes SUL1 and SUL2). Rat sulphate anion transporter 1 (SAT-1). Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD). Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata. Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases. Human protein DRA (Down-Regulated in Adenoma). Soybean early nodulin 70. Escherichia coli hypothetical protein ychM. Caenorhabditis elegans hypothetical protein F41D9.5.
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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