Seroatlas · Human Serome Atlas

SLC26A3

Chloride anion exchanger

Also known as: CLD, DRA, S26A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P40879
Gene
SLC26A3
Ensembl
ENSG00000091138
Chromosome
7
Canonical length
764 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Acrosome

OverviewNCBI Gene

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

764 residues, UniProt reviewed canonical sequence.

>P40879|SLC26A3
     1  MIEPFGNQYI VARPVYSTNA FEENHKKTGR HHKTFLDHLK VCCSCSPQKA KRIVLSLFPI
    61  ASWLPAYRLK EWLLSDIVSG ISTGIVAVLQ GLAFALLVDI PPVYGLYASF FPAIIYLFFG
   121  TSRHISVGPF PILSMMVGLA VSGAVSKAVP DRNATTLGLP NNSNNSSLLD DERVRVAAAA
   181  SVTVLSGIIQ LAFGILRIGF VVIYLSESLI SGFTTAAAVH VLVSQLKFIF QLTVPSHTDP
   241  VSIFKVLYSV FSQIEKTNIA DLVTALIVLL VVSIVKEINQ RFKDKLPVPI PIEFIMTVIA
   301  AGVSYGCDFK NRFKVAVVGD MNPGFQPPIT PDVETFQNTV GDCFGIAMVA FAVAFSVASV
   361  YSLKYDYPLD GNQELIALGL GNIVCGVFRG FAGSTALSRS AVQESTGGKT QIAGLIGAII
   421  VLIVVLAIGF LLAPLQKSVL AALALGNLKG MLMQFAEIGR LWRKDKYDCL IWIMTFIFTI
   481  VLGLGLGLAA SVAFQLLTIV FRTQFPKCST LANIGRTNIY KNKKDYYDMY EPEGVKIFRC
   541  PSPIYFANIG FFRRKLIDAV GFSPLRILRK RNKALRKIRK LQKQGLLQVT PKGFICTVDT
   601  IKDSDEELDN NQIEVLDQPI NTTDLPFHID WNDDLPLNIE VPKISLHSLI LDFSAVSFLD
   661  VSSVRGLKSI LQEFIRIKVD VYIVGTDDDF IEKLNRYEFF DGEVKSSIFF LTIHDAVLHI
   721  LMKKDYSTSK FNPSQEKDGK IDFTINTNGG LRNRVYEVPV ETKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC26A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
1,051 nTPM

Expression across tissuesHPA

Tissue

  • colon: 1,051 nTPM
  • rectum: 826 nTPM
  • duodenum: 543 nTPM
  • seminal vesicle: 123 nTPM
  • small intestine: 112 nTPM
  • breast: 56 nTPM

Single-cell type

  • colonocytes: 4,023 nCPM
  • enterocytes: 1,365 nCPM
  • esophageal apical cells: 569 nCPM
  • neutrophil progenitors: 532 nCPM
  • neutrophils: 420 nCPM
  • late spermatids: 420 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.6 nTPM
  • cerebral cortex: 0.4 nTPM
  • white matter: 0.4 nTPM
  • pons: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC26A3.

Disease | AllUniProt

Conditions SLC26A3 is implicated in, by any mechanism.

  • Diarrhea 1, secretory chloride, congenital (DIAR1) MIM:214700

Disease | GeneticClinVar

132 pathogenic / likely-pathogenic of 886 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC26A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC26A3 as an antibody target. Whether an autoantibody or antibody against SLC26A3 could matter depends on whether native SLC26A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC26A3 is annotated at the cell surface, where native SLC26A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC26A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC26A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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