Seroatlas · Human Serome Atlas

SLC26A11

Sodium-independent sulfate anion transporter

Also known as: S2611_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86WA9
Gene
SLC26A11
Ensembl
ENSG00000181045
Chromosome
17
Canonical length
606 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>Q86WA9|SLC26A11
     1  MPSSVTALGQ ARSSGPGMAP SACCCSPAAL QRRLPILAWL PSYSLQWLKM DFVAGLSVGL
    61  TAIPQALAYA EVAGLPPQYG LYSAFMGCFV YFFLGTSRDV TLGPTAIMSL LVSFYTFHEP
   121  AYAVLLAFLS GCIQLAMGVL RLGFLLDFIS YPVIKGFTSA AAVTIGFGQI KNLLGLQNIP
   181  RPFFLQVYHT FLRIAETRVG DAVLGLVCML LLLVLKLMRD HVPPVHPEMP PGVRLSRGLV
   241  WAATTARNAL VVSFAALVAY SFEVTGYQPF ILTGETAEGL PPVRIPPFSV TTANGTISFT
   301  EMVQDMGAGL AVVPLMGLLE SIAVAKAFAS QNNYRIDANQ ELLAIGLTNM LGSLVSSYPV
   361  TGSFGRTAVN AQSGVCTPAG GLVTGVLVLL SLDYLTSLFY YIPKSALAAV IIMAVAPLFD
   421  TKIFRTLWRV KRLDLLPLCV TFLLCFWEVQ YGILAGALVS LLMLLHSAAR PETKVSEGPV
   481  LVLQPASGLS FPAMEALREE ILSRALEVSP PRCLVLECTH VCSIDYTVVL GLGELLQDFQ
   541  KQGVALAFVG LQVPVLRVLL SADLKGFQYF STLEEAEKHL RQEPGTQPYN IREDSILDQK
   601  VALLKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC26A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 37 nTPM
  • adrenal gland: 35 nTPM
  • pituitary gland: 34 nTPM
  • thyroid gland: 24 nTPM
  • ovary: 22 nTPM
  • spleen: 22 nTPM

Single-cell type

  • adrenal medulla cells: 96 nCPM
  • adrenal cortex cells: 66 nCPM
  • other brain neurons: 61 nCPM
  • syncytiotrophoblasts: 45 nCPM
  • cone photoreceptor cells: 41 nCPM
  • choroid plexus epithelial cells: 39 nCPM

Immune cell

  • naive CD4 T-cell: 1.9 nTPM
  • T-reg: 1.7 nTPM
  • memory CD4 T-cell: 1.2 nTPM
  • MAIT T-cell: 1.1 nTPM
  • classical monocyte: 1 nTPM
  • memory CD8 T-cell: 1 nTPM

Brain region

  • hypothalamus: 84 nTPM
  • midbrain: 59 nTPM
  • pons: 52 nTPM
  • medulla oblongata: 46 nTPM
  • thalamus: 45 nTPM
  • basal ganglia: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC26A11 as an antibody target. Whether an autoantibody or antibody against SLC26A11 could matter depends on whether native SLC26A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC26A11 is annotated at the cell surface, where native SLC26A11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC26A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC26A11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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