Seroatlas · Human Serome Atlas

SLC26A2

Sulfate transporter

Also known as: DTD, DTDST, S26A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50443
Gene
SLC26A2
Ensembl
ENSG00000155850
Chromosome
5
Canonical length
739 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

739 residues, UniProt reviewed canonical sequence.

>P50443|SLC26A2
     1  MSSESKEQHN VSPRDSAEGN DSYPSGIHLE LQRESSTDFK QFETNDQCRP YHRILIERQE
    61  KSDTNFKEFV IKKLQKNCQC SPAKAKNMIL GFLPVLQWLP KYDLKKNILG DVMSGLIVGI
   121  LLVPQSIAYS LLAGQEPVYG LYTSFFASII YFLLGTSRHI SVGIFGVLCL MIGETVDREL
   181  QKAGYDNAHS APSLGMVSNG STLLNHTSDR ICDKSCYAIM VGSTVTFIAG VYQVAMGFFQ
   241  VGFVSVYLSD ALLSGFVTGA SFTILTSQAK YLLGLNLPRT NGVGSLITTW IHVFRNIHKT
   301  NLCDLITSLL CLLVLLPTKE LNEHFKSKLK APIPIELVVV VAATLASHFG KLHENYNSSI
   361  AGHIPTGFMP PKVPEWNLIP SVAVDAIAIS IIGFAITVSL SEMFAKKHGY TVKANQEMYA
   421  IGFCNIIPSF FHCFTTSAAL AKTLVKESTG CHTQLSGVVT ALVLLLVLLV IAPLFYSLQK
   481  SVLGVITIVN LRGALRKFRD LPKMWSISRM DTVIWFVTML SSALLSTEIG LLVGVCFSIF
   541  CVILRTQKPK SSLLGLVEES EVFESVSAYK NLQIKPGIKI FRFVAPLYYI NKECFKSALY
   601  KQTVNPILIK VAWKKAAKRK IKEKVVTLGG IQDEMSVQLS HDPLELHTIV IDCSAIQFLD
   661  TAGIHTLKEV RRDYEAIGIQ VLLAQCNPTV RDSLTNGEYC KKEEENLLFY SVYEAMAFAE
   721  VSKNQKGVCV PNGLSLSSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC26A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
198 nTPM

Expression across tissuesHPA

Tissue

  • colon: 198 nTPM
  • rectum: 178 nTPM
  • parathyroid gland: 35 nTPM
  • salivary gland: 35 nTPM
  • placenta: 32 nTPM
  • adrenal gland: 29 nTPM

Single-cell type

  • colonocytes: 2,058 nCPM
  • endometrial luminal cells: 1,205 nCPM
  • syncytiotrophoblasts: 1,035 nCPM
  • endometrial glandular cells: 673 nCPM
  • mast cells: 301 nCPM
  • cytotrophoblasts: 288 nCPM

Immune cell

  • basophil: 4.1 nTPM
  • non-classical monocyte: 1.5 nTPM
  • MAIT T-cell: 1 nTPM
  • gdT-cell: 0.8 nTPM
  • T-reg: 0.8 nTPM
  • memory CD8 T-cell: 0.7 nTPM

Brain region

  • cerebellum: 20 nTPM
  • choroid plexus: 9 nTPM
  • thalamus: 9 nTPM
  • medulla oblongata: 8.5 nTPM
  • spinal cord: 8.5 nTPM
  • pons: 7.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC26A2.

Disease | AllUniProt

Conditions SLC26A2 is implicated in, by any mechanism.

Disease | GeneticClinVar

241 pathogenic / likely-pathogenic of 952 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Achondrogenesis, type IB
  • Multiple epiphyseal dysplasia type 4
  • Diastrophic dysplasia
  • Atelosteogenesis type II
  • Sulfate transporter-related osteochondrodysplasia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC26A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC26A2 as an antibody target. Whether an autoantibody or antibody against SLC26A2 could matter depends on whether native SLC26A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC26A2 is annotated at the cell surface, where native SLC26A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC26A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC26A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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