Seroatlas · Human Serome Atlas

SLC26A7

Anion exchange transporter

Also known as: S26A7_HUMAN, SUT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TE54
Gene: SLC26A7
Ensembl: ENSG00000147606
Chromosome: 8
Canonical length: 656 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles,Perinuclear theca,Mid piece

OverviewNCBI Gene

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

656 residues, UniProt reviewed canonical sequence.

>Q8TE54|SLC26A7
     1  MTGAKRKKKS MLWSKMHTPQ CEDIIQWCRR RLPILDWAPH YNLKENLLPD TVSGIMLAVQ
    61  QVTQGLAFAV LSSVHPVFGL YGSLFPAIIY AIFGMGHHVA TGTFALTSLI SANAVERIVP
   121  QNMQNLTTQS NTSVLGLSDF EMQRIHVAAA VSFLGGVIQV AMFVLQLGSA TFVVTEPVIS
   181  AMTTGAATHV VTSQVKYLLG MKMPYISGPL GFFYIYAYVF ENIKSVRLEA LLLSLLSIVV
   241  LVLVKELNEQ FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PQGIPSPRAP
   301  PMNILSAVIT EAFGVALVGY VASLALAQGS AKKFKYSIDD NQEFLAHGLS NIVSSFFFCI
   361  PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL LYWLPMCVLA SIIVVGLKGM
   421  LIQFRDLKKY WNVDKIDWGI WVSTYVFTIC FAANVGLLFG VVCTIAIVIG RFPRAMTVSI
   481  KNMKEMEFKV KTEMDSETLQ QVKIISINNP LVFLNAKKFY TDLMNMIQKE NACNQPLDDI
   541  SKCEQNTLLN SLSNGNCNEE ASQSCPNEKC YLILDCSGFT FFDYSGVSML VEVYMDCKGR
   601  SVDVLLAHCT ASLIKAMTYY GNLDSEKPIF FESVSAAISH IHSNKNLSKL SDHSEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC26A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 310 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 310 nTPM
kidney: 22 nTPM
stomach: 5.7 nTPM
lymph node: 3.5 nTPM
endometrium: 2.5 nTPM
adipose tissue: 1.4 nTPM

Single-cell type

renal collecting duct intercalated cells: 3,971 nCPM
retinal pigment epithelial cells: 196 nCPM
endometrial luminal cells: 142 nCPM
renal connecting tubule cells: 109 nCPM
parietal cells: 81 nCPM
neuroendocrine cells: 67 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1.1 nTPM
basal ganglia: 0.8 nTPM
pons: 0.8 nTPM
choroid plexus: 0.7 nTPM
medulla oblongata: 0.7 nTPM
thalamus: 0.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC26A7.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 122 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Congenital hypothyroidism

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC26A7 as an antibody target. Whether an autoantibody or antibody against SLC26A7 could matter depends on whether native SLC26A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC26A7 is annotated at the cell surface, where native SLC26A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC26A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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