Seroatlas · Human Serome Atlas

SLC26A1

Sulfate anion transporter 1

Also known as: EDM4, S26A1_HUMAN, SAT-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2B4
Gene
SLC26A1
Ensembl
ENSG00000145217
Chromosome
4
Canonical length
701 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Microtubules

OverviewNCBI Gene

This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

701 residues, UniProt reviewed canonical sequence.

>Q9H2B4|SLC26A1
     1  MDESPEPLQQ GRGPVPVRRQ RPAPRGLREM LKARLWCSCS CSVLCVRALV QDLLPATRWL
    61  RQYRPREYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY SLYTSFFANL IYFLMGTSRH
   121  VSVGIFSLLC LMVGQVVDRE LQLAGFDPSQ DGLQPGANSS TLNGSAAMLD CGRDCYAIRV
   181  ATALTLMTGL YQVLMGVLRL GFVSAYLSQP LLDGFAMGAS VTILTSQLKH LLGVRIPRHQ
   241  GPGMVVLTWL SLLRGAGQAN VCDVVTSTVC LAVLLAAKEL SDRYRHRLRV PLPTELLVIV
   301  VATLVSHFGQ LHKRFGSSVA GDIPTGFMPP QVPEPRLMQR VALDAVALAL VAAAFSISLA
   361  EMFARSHGYS VRANQELLAV GCCNVLPAFL HCFATSAALA KSLVKTATGC RTQLSSVVSA
   421  TVVLLVLLAL APLFHDLQRS VLACVIVVSL RGALRKVWDL PRLWRMSPAD ALVWAGTAAT
   481  CMLVSTEAGL LAGVILSLLS LAGRTQRPRT ALLARIGDTA FYEDATEFEG LVPEPGVRVF
   541  RFGGPLYYAN KDFFLQSLYS LTGLDAGCMA ARRKEGGSET GVGEGGPAQG EDLGPVSTRA
   601  ALVPAAAGFH TVVIDCAPLL FLDAAGVSTL QDLRRDYGAL GISLLLACCS PPVRDILSRG
   661  GFLGEGPGDT AEEEQLFLSV HDAVQTARAR HRELEATDAH L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC26A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • liver: 17 nTPM
  • adrenal gland: 7.1 nTPM
  • kidney: 5.5 nTPM
  • cerebellum: 5.3 nTPM
  • duodenum: 4.9 nTPM
  • small intestine: 4.3 nTPM

Single-cell type

  • epicardial cells: 18 nCPM
  • hepatocytes: 13 nCPM
  • adipocytes: 11 nCPM
  • cardiomyocytes: 10 nCPM
  • enterocytes: 6.3 nCPM
  • proximal tubule cells: 6.1 nCPM

Immune cell

  • basophil: 5.4 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • T-reg: 0.8 nTPM
  • NK-cell: 0.6 nTPM
  • memory CD4 T-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • cerebellum: 18 nTPM
  • medulla oblongata: 15 nTPM
  • pons: 14 nTPM
  • cerebral cortex: 13 nTPM
  • hippocampal formation: 13 nTPM
  • midbrain: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC26A1.

Disease | AllUniProt

Conditions SLC26A1 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 538 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Nephrolithiasis, calcium oxalate
  • Hypersulfaturia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC26A1 as an antibody target. Whether an autoantibody or antibody against SLC26A1 could matter depends on whether native SLC26A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC26A1 is annotated at the cell surface, where native SLC26A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC26A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC26A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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