Seroatlas · Human Serome Atlas

CARHSP1

Calcium-regulated heat-stable protein 1

Also known as: CHSP1_HUMAN, CRHSP-24, CSDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2V2
Gene: CARHSP1
Ensembl: ENSG00000153048
Chromosome: 16
Canonical length: 147 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule; cytoplasmic exosome (RNase complex); and cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q9Y2V2|CARHSP1
     1  MSSEPPPPPQ PPTHQASVGL LDTPRSRERS PSPLRGNVVP SPLPTRRTRT FSATVRASQG
    61  PVYKGVCKCF CRSKGHGFIT PADGGPDIFL HISDVEGEYV PVEGDEVTYK MCSIPPKNEK
   121  LQAVEVVITH LAPGTKHETW SGHVISS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CARHSP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 404 nTPM

Expression across tissuesHPA

Tissue

testis: 404 nTPM
esophagus: 181 nTPM
liver: 176 nTPM
adrenal gland: 121 nTPM
lung: 108 nTPM
basal ganglia: 101 nTPM

Single-cell type

late spermatids: 12,215 nCPM
esophageal apical cells: 4,462 nCPM
early spermatids: 2,193 nCPM
late primary spermatocytes: 879 nCPM
esophageal suprabasal cells: 674 nCPM
oocytes: 442 nCPM

Immune cell

neutrophil: 89 nTPM
basophil: 76 nTPM
T-reg: 63 nTPM
plasmacytoid DC: 47 nTPM
NK-cell: 42 nTPM
eosinophil: 36 nTPM

Brain region

basal ganglia: 93 nTPM
white matter: 64 nTPM
medulla oblongata: 57 nTPM
thalamus: 47 nTPM
cerebral cortex: 47 nTPM
pons: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -2.38
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CARHSP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STYX

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CARHSP1 as an antibody target. Whether an autoantibody or antibody against CARHSP1 could matter depends on whether native CARHSP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CARHSP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CARHSP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...