YBX2

Protein identityUniProt · HPA

UniProt accession

Q9Y2T7

Gene

YBX2

Ensembl

ENSG00000006047

Chromosome

17

Canonical length

364 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q9Y2T7|YBX2
     1  MSEVEAAAGA TAVPAATVPA TAAGVVAVVV PVPAGEPQKG GGAGGGGGAA SGPAAGTPSA
    61  PGSRTPGNPA TAVSGTPAPP ARSQADKPVL AIQVLGTVKW FNVRNGYGFI NRNDTKEDVF
   121  VHQTAIKRNN PRKFLRSVGD GETVEFDVVE GEKGAEATNV TGPGGVPVKG SRYAPNRRKS
   181  RRFIPRPPSV APPPMVAEIP SAGTGPGSKG ERAEDSGQRP RRWCPPPFFY RRRFVRGPRP
   241  PNQQQPIEGT DRVEPKETAP LEGHQQQGDE RVPPPRFRPR YRRPFRPRPR QQPTTEGGDG
   301  ETKPSQGPAD GSRPEPQRPR NRPYFQRRRQ QAPGPQQAPG PRQPAAPETS APVNSGDPTT
   361  TILE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YBX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

493 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YBX2.

Disease | ImmuneIEDB

Conditions an epitope on YBX2 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.15

gnomAD pLI

1

gnomAD missense Z

1.6

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• oocyte development
• positive regulation of cold-induced thermogenesis
• regulation of gene expression
• spermatogenesis
• transcription by RNA polymerase II
• translational attenuation

Molecular functions

• DNA binding
• nucleic acid binding
• RNA binding

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Cold-shock protein Csp, DNA-binding
• Cold-shock domain
• Nucleic acid-binding, OB-fold
• Cold-shock domain, conserved site
• Cold shock domain-containing protein
• 'Cold-shock' DNA-binding domain

KeywordsUniProt

• Cytoplasm
• DNA-binding
• Nucleus
• Phosphoprotein
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of YBX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ZAR1L
• ZAR1
• YBX1