CSDC2
Cold shock domain-containing protein C2
Also known as: CSDC2_HUMAN, PIPPin
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y534
- Gene
- CSDC2
- Ensembl
- ENSG00000172346
- Chromosome
- 22
- Canonical length
- 153 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
153 residues, UniProt reviewed canonical sequence.
>Q9Y534|CSDC2
1 MTSESTSPPV VPPLHSPKSP VWPTFPFHRE GSRVWERGGV PPRDLPSPLP TKRTRTYSAT
61 ARASAGPVFK GVCKQFSRSQ GHGFITPENG SEDIFVHVSD IEGEYVPVEG DEVTYKMCPI
121 PPKNQKFQAV EVVLTQLAPH TPHETWSGQV VGSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CSDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 301 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 301 nTPM
- adrenal gland: 154 nTPM
- ovary: 143 nTPM
- blood vessel: 101 nTPM
- endometrium: 82 nTPM
- cerebellum: 81 nTPM
Single-cell type
- ovarian stromal cells: 148 nCPM
- cardiomyocytes: 118 nCPM
- müller glia: 87 nCPM
- decidual stromal cells: 81 nCPM
- sertoli cells: 78 nCPM
- vascular smooth muscle cells: 76 nCPM
Immune cell
- eosinophil: 0.2 nTPM
- T-reg: 0.2 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0.1 nTPM
- gdT-cell: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
Brain region
- cerebellum: 135 nTPM
- thalamus: 98 nTPM
- medulla oblongata: 96 nTPM
- midbrain: 89 nTPM
- pons: 78 nTPM
- hypothalamus: 76 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.67
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.79
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CSDC2 as an antibody target. Whether an autoantibody or antibody against CSDC2 could matter depends on whether native CSDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CSDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CSDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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