Reverse transcriptase thumb

Definition

This domain is known as the thumb domain. It is composed of a four helix bundle PMID:1377403. Reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. Reverse transcriptase often occurs in a polyprotein; with integrase, ribonuclease H and/or protease, which is cleaved before the enzyme takes action. The impact of antiretroviral treatment on the first 400 amino acids of HIV reverse transcriptase is good. Little is known, however, of the antiretroviral drug impact on the C-terminal domains of Pol, which includes the thumb, connection and RNase H PMID:18335052. Evidence suggests that these might be well conserved domains.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• ERVK-10
• ERVK-11
• ERVK-18
• ERVK-19
• ERVK-25
• ERVK-6
• ERVK-7
• ERVK-8
• HERVK_113