Di19, zinc-binding domain

Definition

This zinc-binding domain is found in Di19 proteins, animal E3 ubiquitin-protein ligases (RNF114/KCMF1/RNF138/RNF125/RNF166) and transcriptional repressors (ZEB1/ZEB2). KCMF1 and RNF114 are E3 ubiquitin-protein ligases [[cite:PMID:15581609], [cite:PMID:23645206]], while ZEB1 represses transcription by binding to the E box (5'-CANNTG-3') PMID:19935649. In RNF114, this domain has been shown to be essential for mono-ADPr-dependent recruitment to DNA lesions PMID:37116497. Protein dehydration-induced19 (Di19) increases the sensitivity of plants to environmental stress, such as salinity, drought, osmotic stress and cold. The protein is also induced by an increased supply of stress-related hormones such as abscisic acid ABA and ethylene PMID:19895399. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought PMID:7823904. It is phosphorylated by AtCPK11 in a Ca(2+)-dependent manner PMID:16438971

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• KCMF1
• RNF114
• RNF125
• RNF138
• RNF166
• ZEB1
• ZEB2