Tropomodulin

Definition

Actin filaments have an intrinsic polarity, each with a fast-growing (barbed) end and a slow-growing (pointed) end. The slow-growing end is regulated by tropomodulins, a family of capping proteins that require tropomyosins for optimal function PMID:19216712. Tropomyosins contains two domains: an N-terminal unstructured tropomyosin-binding region which has an actin pointed-end-capping activity, an C-terminal region that contains one compact domain represented by alternating α-helices and β-structures PMID:19216712. The tropomyosin-independent actin-capping site is located at the C terminus PMID:19216712. The structure of tropomyosin-1 has been solved PMID:25061212. Proteins in this entry include Tropomodulin (TMOD)-1/2/3/4 and Leiomodin (LMOD)-1/2/3.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• LMOD1
• LMOD2
• LMOD3
• TMOD1
• TMOD2
• TMOD3
• TMOD4