Seroatlas · Human Serome Atlas

TMOD2

Tropomodulin-2

Also known as: NTMOD, TMOD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZR1
Gene
TMOD2
Ensembl
ENSG00000128872
Chromosome
15
Canonical length
351 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q9NZR1|TMOD2
     1  MALPFQKELE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESAMLPAGF RQKDQTQKAA
    61  TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP KEKPIETRKE EKVTLDPELE
   121  EALASASDTE LYDLAAVLGV HNLLNNPKFD EETANNKGGK GPVRNVVKGE KVKPVFEEPP
   181  NPTNVEISLQ QMKANDPSLQ EVNLNNIKNI PIPTLREFAK ALETNTHVKK FSLAATRSND
   241  PVAIAFADML KVNKTLTSLN IESNFITGTG ILALVEALKE NDTLTEIKID NQRQQLGTAV
   301  EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEADR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMOD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 63 nTPM
  • amygdala: 40 nTPM
  • basal ganglia: 36 nTPM
  • hippocampal formation: 33 nTPM
  • cerebellum: 33 nTPM
  • hypothalamus: 29 nTPM

Single-cell type

  • schwann cells: 270 nCPM
  • bergmann glia: 171 nCPM
  • brain excitatory neurons: 135 nCPM
  • oligodendrocyte progenitor cells: 119 nCPM
  • brain inhibitory neurons: 119 nCPM
  • other brain neurons: 110 nCPM

Immune cell

  • neutrophil: 13 nTPM
  • non-classical monocyte: 11 nTPM
  • eosinophil: 8.6 nTPM
  • classical monocyte: 5.9 nTPM
  • memory B-cell: 2.7 nTPM
  • intermediate monocyte: 2.4 nTPM

Brain region

  • cerebral cortex: 214 nTPM
  • basal ganglia: 169 nTPM
  • hippocampal formation: 146 nTPM
  • amygdala: 142 nTPM
  • white matter: 140 nTPM
  • pons: 131 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.02
gnomAD missense Z
0.39
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMOD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMOD2 as an antibody target. Whether an autoantibody or antibody against TMOD2 could matter depends on whether native TMOD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMOD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMOD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMOD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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