Seroatlas · Human Serome Atlas

TMOD4

Tropomodulin-4

Also known as: Sk-Tmod, TMOD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZQ9
Gene: TMOD4
Ensembl: ENSG00000163157
Chromosome: 1
Canonical length: 345 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Located in striated muscle thin filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9NZQ9|TMOD4
     1  MSSYQKELEK YRDIDEDEIL RTLSPEELEQ LDCELQEMDP ENMLLPAGLR QRDQTKKSPT
    61  GPLDREALLQ YLEQQALEVK ERDDLVPFTG EKKGKPYIQP KREIPAEEQI TLEPELEEAL
   121  AHATDAEMCD IAAILDMYTL MSNKQYYDAL CSGEICNTEG ISSVVQPDKY KPVPDEPPNP
   181  TNIEEILKRV RSNDKELEEV NLNNIQDIPI PMLSELCEAM KANTYVRSFS LVATRSGDPI
   241  ANAVADMLRE NRSLQSLNIE SNFISSTGLM AVLKAVRENA TLTELRVDNQ RQWPGDAVEM
   301  EMATVLEQCP SIVRFGYHFT QQGPRARAAQ AMTRNNELRR QQKKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMOD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 1,149 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,149 nTPM
tongue: 499 nTPM
esophagus: 12 nTPM
prostate: 9.4 nTPM
salivary gland: 8.3 nTPM
tonsil: 6.6 nTPM

Single-cell type

myonuclei: 137 nCPM
thymic myoid cells: 34 nCPM
respiratory ionocytes: 20 nCPM
sertoli cells: 5.9 nCPM
salivary ionocytes: 5.1 nCPM
late spermatids: 4.6 nCPM

Immune cell

naive CD8 T-cell: 0.9 nTPM
gdT-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM
memory B-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM

Brain region

choroid plexus: 3.1 nTPM
cerebral cortex: 2.1 nTPM
midbrain: 2.1 nTPM
hippocampal formation: 1.9 nTPM
amygdala: 1.8 nTPM
basal ganglia: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.71
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMOD4 as an antibody target. Whether an autoantibody or antibody against TMOD4 could matter depends on whether native TMOD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMOD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMOD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...