Sodium/calcium exchanger membrane region

Definition

The sodium/calcium exchangers are a family of integral membrane proteins. This domain covers the integral membrane regions of these proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells PMID:1700476. Ca2+ is moved into or out of the cytosol depending on Na+ concentration PMID:1700476. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 PMID:8798769.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• SLC24A1
• SLC24A2
• SLC24A3
• SLC24A4
• SLC24A5
• SLC8A1
• SLC8A2
• SLC8A3
• SLC8B1