Seroatlas · Human Serome Atlas

SLC24A2

Sodium/potassium/calcium exchanger 2

Also known as: NCKX2, NCKX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UI40
Gene
SLC24A2
Ensembl
ENSG00000155886
Chromosome
9
Canonical length
661 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

661 residues, UniProt reviewed canonical sequence.

>Q9UI40|SLC24A2
     1  MDLQQSTTIT SLEKWCLDES LSGCRRHYSV KKKLKLIRVL GLFMGLVAIS TVSFSISAFS
    61  ETDTQSTGEA SVVSGPRVAQ GYHQRTLLDL NDKILDYTPQ PPLSKEGESE NSTDHAQGDY
   121  PKDIFSLEER RKGAIILHVI GMIYMFIALA IVCDEFFVPS LTVITEKLGI SDDVAGATFM
   181  AAGGSAPELF TSLIGVFIAH SNVGIGTIVG SAVFNILFVI GMCALFSREI LNLTWWPLFR
   241  DVSFYIVDLI MLIIFFLDNV IMWWESLLLL TAYFCYVVFM KFNVQVEKWV KQMINRNKVV
   301  KVTAPEAQAK PSAARDKDEP TLPAKPRLQR GGSSASLHNS LMRNSIFQLM IHTLDPLAEE
   361  LGSYGKLKYY DTMTEEGRFR EKASILHKIA KKKCHVDENE RQNGAANHVE KIELPNSTST
   421  DVEMTPSSDA SEPVQNGNLS HNIEGAEAQT ADEEEDQPLS LAWPSETRKQ VTFLIVFPIV
   481  FPLWITLPDV RKPSSRKFFP ITFFGSITWI AVFSYLMVWW AHQVGETIGI SEEIMGLTIL
   541  AAGTSIPDLI TSVIVARKGL GDMAVSSSVG SNIFDITVGL PLPWLLYTVI HRFQPVAVSS
   601  NGLFCAIVLL FIMLLFVILS IALCKWRMNK ILGFIMFGLY FVFLVVSVLL EDRILTCPVS
   661  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC24A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 26 nTPM
  • spinal cord: 21 nTPM
  • basal ganglia: 21 nTPM
  • hippocampal formation: 17 nTPM
  • retina: 15 nTPM
  • midbrain: 15 nTPM

Single-cell type

  • oligodendrocytes: 3,413 nCPM
  • cone photoreceptor cells: 2,155 nCPM
  • retinal horizontal cells: 811 nCPM
  • adrenal medulla cells: 798 nCPM
  • brain inhibitory neurons: 567 nCPM
  • gonadotrophs: 481 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • neutrophil: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM

Brain region

  • pons: 195 nTPM
  • white matter: 190 nTPM
  • thalamus: 184 nTPM
  • cerebral cortex: 158 nTPM
  • medulla oblongata: 140 nTPM
  • basal ganglia: 136 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.01
gnomAD missense Z
-0.21
DepMap mean gene effect
0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC24A2 as an antibody target. Whether an autoantibody or antibody against SLC24A2 could matter depends on whether native SLC24A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC24A2 is annotated at the cell surface, where native SLC24A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC24A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC24A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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