Seroatlas · Human Serome Atlas

SLC8B1

Mitochondrial sodium/calcium exchanger protein

Also known as: FLJ22233, NCKX6, NCLX, NCLX_HUMAN, SLC24A6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6J4K2
Gene
SLC8B1
Ensembl
ENSG00000089060
Chromosome
12
Canonical length
584 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>Q6J4K2|SLC8B1
     1  MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV VDCRKVCGLN
    61  VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV TLYVSWLLYL FLILGVTAAK
   121  FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG APDIFSALVA FSDPHTAGLA LGALFGAGVL
   181  VTTVVAGGIT ILHPFMAASR PFFRDIVFYM VAVFLTFLML FRGRVTLAWA LGYLGLYVFY
   241  VVTVILCTWI YQRQRRGSLF CPMPVTPEIL SDSEEDRVSS NTNSYDYGDE YRPLFFYQET
   301  TAQILVRALN PLDYMKWRRK SAYWKALKVF KLPVEFLLLL TVPVVDPDKD DQNWKRPLNC
   361  LHLVISPLVV VLTLQSGTYG VYEIGGLVPV WVVVVIAGTA LASVTFFATS DSQPPRLHWL
   421  FAFLGFLTSA LWINAAATEV VNILRSLGVV FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR
   481  QGYPRMAFSA CFGGIIFNIL VGVGLGCLLQ ISRSHTEVKL EPDGLLVWVL AGALGLSLVF
   541  SLVSVPLQCF QLSRVYGFCL LLFYLNFLVV ALLTEFGVIH LKSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC8B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
13
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 71 nTPM
  • ovary: 54 nTPM
  • spleen: 28 nTPM
  • lung: 20 nTPM
  • skin: 19 nTPM
  • adipose tissue: 18 nTPM

Single-cell type

  • somatotrophs: 338 nCPM
  • adrenal cortex cells: 209 nCPM
  • monocytes: 110 nCPM
  • macrophages: 96 nCPM
  • neutrophil progenitors: 88 nCPM
  • thyrotrophs: 71 nCPM

Immune cell

  • eosinophil: 33 nTPM
  • naive CD4 T-cell: 29 nTPM
  • non-classical monocyte: 25 nTPM
  • intermediate monocyte: 24 nTPM
  • T-reg: 19 nTPM
  • myeloid DC: 19 nTPM

Brain region

  • medulla oblongata: 33 nTPM
  • thalamus: 28 nTPM
  • white matter: 25 nTPM
  • pons: 25 nTPM
  • basal ganglia: 24 nTPM
  • midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC8B1 as an antibody target. Whether an autoantibody or antibody against SLC8B1 could matter depends on whether native SLC8B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC8B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC8B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC8B1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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