Seroatlas · Human Serome Atlas

SLC8A1

Sodium/calcium exchanger 1

Also known as: NAC1_HUMAN, NCX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32418
Gene
SLC8A1
Ensembl
ENSG00000183023
Chromosome
2
Canonical length
973 aa
Protein class
FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

973 residues, UniProt reviewed canonical sequence.

>P32418|SLC8A1
     1  MYNMRRLSLS PTFSMGFHLL VTVSLLFSHV DHVIAETEME GEGNETGECT GSYYCKKGVI
    61  LPIWEPQDPS FGDKIARATV YFVAMVYMFL GVSIIADRFM SSIEVITSQE KEITIKKPNG
   121  ETTKTTVRIW NETVSNLTLM ALGSSAPEIL LSVIEVCGHN FTAGDLGPST IVGSAAFNMF
   181  IIIALCVYVV PDGETRKIKH LRVFFVTAAW SIFAYTWLYI ILSVISPGVV EVWEGLLTFF
   241  FFPICVVFAW VADRRLLFYK YVYKRYRAGK QRGMIIEHEG DRPSSKTEIE MDGKVVNSHV
   301  ENFLDGALVL EVDERDQDDE EARREMARIL KELKQKHPDK EIEQLIELAN YQVLSQQQKS
   361  RAFYRIQATR LMTGAGNILK RHAADQARKA VSMHEVNTEV TENDPVSKIF FEQGTYQCLE
   421  NCGTVALTII RRGGDLTNTV FVDFRTEDGT ANAGSDYEFT EGTVVFKPGD TQKEIRVGII
   481  DDDIFEEDEN FLVHLSNVKV SSEASEDGIL EANHVSTLAC LGSPSTATVT IFDDDHAGIF
   541  TFEEPVTHVS ESIGIMEVKV LRTSGARGNV IVPYKTIEGT ARGGGEDFED TCGELEFQND
   601  EIVKTISVKV IDDEEYEKNK TFFLEIGEPR LVEMSEKKAL LLNELGGFTI TGKYLFGQPV
   661  FRKVHAREHP ILSTVITIAD EYDDKQPLTS KEEEERRIAE MGRPILGEHT KLEVIIEESY
   721  EFKSTVDKLI KKTNLALVVG TNSWREQFIE AITVSAGEDD DDDECGEEKL PSCFDYVMHF
   781  LTVFWKVLFA FVPPTEYWNG WACFIVSILM IGLLTAFIGD LASHFGCTIG LKDSVTAVVF
   841  VALGTSVPDT FASKVAATQD QYADASIGNV TGSNAVNVFL GIGVAWSIAA IYHAANGEQF
   901  KVSPGTLAFS VTLFTIFAFI NVGVLLYRRR PEIGGELGGP RTAKLLTSCL FVLLWLLYIF
   961  FSSLEAYCHI KGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC8A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
144 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 144 nTPM
  • seminal vesicle: 34 nTPM
  • smooth muscle: 27 nTPM
  • endometrium: 25 nTPM
  • prostate: 24 nTPM
  • kidney: 20 nTPM

Single-cell type

  • cardiomyocytes: 14,581 nCPM
  • renal connecting tubule cells: 12,731 nCPM
  • neutrophils: 8,664 nCPM
  • distal convoluted tubule cells: 2,715 nCPM
  • microglia: 2,153 nCPM
  • brain inhibitory neurons: 1,349 nCPM

Immune cell

  • neutrophil: 40 nTPM
  • non-classical monocyte: 12 nTPM
  • intermediate monocyte: 9.1 nTPM
  • classical monocyte: 7.9 nTPM
  • myeloid DC: 4.5 nTPM
  • total PBMC: 1.4 nTPM

Brain region

  • cerebral cortex: 183 nTPM
  • white matter: 171 nTPM
  • hippocampal formation: 166 nTPM
  • basal ganglia: 160 nTPM
  • midbrain: 147 nTPM
  • thalamus: 147 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.2
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC8A1 as an antibody target. Whether an autoantibody or antibody against SLC8A1 could matter depends on whether native SLC8A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC8A1 is annotated at the cell surface, where native SLC8A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC8A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC8A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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