Seroatlas · Human Serome Atlas

SLC24A3

Sodium/potassium/calcium exchanger 3

Also known as: NCKX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HC58
Gene
SLC24A3
Ensembl
ENSG00000185052
Chromosome
20
Canonical length
644 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

644 residues, UniProt reviewed canonical sequence.

>Q9HC58|SLC24A3
     1  MRPSGDEDRA RRRRRRRRRR DLLLSQLCFL ASVALLLWSL SSLREQKELD LMDLVGEDRK
    61  WMMARKLMQV NDTLTSEDAG LRNSKNCTEP ALHEFPNDIF TNEDRRQGAV VLHVLCAIYM
   121  FYALAIVCDD FFVPSLEKIC ERLHLSEDVA GATFMAAGSS APELFTSVIG VFITKGDVGV
   181  GTIVGSAVFN ILCIIGVCGL FAGQVVALSS WCLLRDSIYY TLSVIALIVF IYDEKVSWWE
   241  SLVLVLMYLI YIVIMKYNAC IHQCFERRTK GAGNMVNGLA NNAEIDDSSN CDATVVLLKK
   301  ANFHRKASVI MVDELLSAYP HQLSFSEAGL RIMITSHFPP KTRLSMASRM LINERQRLIN
   361  SRAYTNGESE VAIKIPIKHT VENGTGPSSA PDRGVNGTRR DDVVAEAGNE TENENEDNEN
   421  DEEEEEDEDD DEGPYTPFDT PSGKLETVKW AFTWPLSFVL YFTVPNCNKP RWEKWFMVTF
   481  ASSTLWIAAF SYMMVWMVTI IGYTLGIPDV IMGITFLAAG TSVPDCMASL IVARQGMGDM
   541  AVSNSIGSNV FDILIGLGLP WALQTLAVDY GSYIRLNSRG LIYSVGLLLA SVFVTVFGVH
   601  LNKWQLDKKL GCGCLLLYGV FLCFSIMTEF NVFTFVNLPM CGDH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC24A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 38 nTPM
  • hippocampal formation: 36 nTPM
  • endometrium: 36 nTPM
  • fallopian tube: 30 nTPM
  • smooth muscle: 27 nTPM
  • blood vessel: 24 nTPM

Single-cell type

  • mast cells: 2,522 nCPM
  • megakaryocyte progenitors: 956 nCPM
  • endometrial stromal cells: 842 nCPM
  • oligodendrocyte progenitor cells: 619 nCPM
  • bergmann glia: 424 nCPM
  • esophageal apical cells: 398 nCPM

Immune cell

  • basophil: 5.7 nTPM
  • eosinophil: 1.9 nTPM
  • total PBMC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hippocampal formation: 175 nTPM
  • cerebral cortex: 118 nTPM
  • thalamus: 73 nTPM
  • midbrain: 41 nTPM
  • hypothalamus: 40 nTPM
  • amygdala: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.88
gnomAD missense Z
2.09
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC24A3 as an antibody target. Whether an autoantibody or antibody against SLC24A3 could matter depends on whether native SLC24A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC24A3 is annotated at the cell surface, where native SLC24A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC24A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC24A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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