SLC8A3

Protein identityUniProt · HPA

UniProt accession

P57103

Gene

SLC8A3

Ensembl

ENSG00000100678

Chromosome

14

Canonical length

927 aa

Protein class

Metabolic proteins, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Centrosome,Cytosol,Acrosome,End piece

OverviewNCBI Gene

This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

927 residues, UniProt reviewed canonical sequence.

>P57103|SLC8A3
     1  MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL
    61  PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE
   121  TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI
   181  IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF
   241  FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN
   301  LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR
   361  MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR
   421  KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF
   481  FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH
   541  VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV
   601  KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK RIAEMGKPVL
   661  GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD QFMEAITVSA AGDEDEDESG
   721  EERLPSCFDY VMHFLTVFWK VLFACVPPTE YCHGWACFAV SILIIGMLTA IIGDLASHFG
   781  CTIGLKDSVT AVVFVAFGTS VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW
   841  SVAAIYWALQ GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA
   901  TTWLFVSLWL LYILFATLEA YCYIKGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC8A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

11

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

19 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.59

gnomAD pLI

0

gnomAD missense Z

0.42

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium ion export across plasma membrane
• calcium ion import across plasma membrane
• calcium ion transmembrane transport
• calcium ion transport into cytosol
• cell communication
• cellular response to cAMP
• cellular response to hypoxia
• hematopoietic progenitor cell differentiation
• intracellular calcium ion homeostasis
• learning
• learning or memory
• long-term synaptic potentiation
• memory
• mitochondrial calcium ion homeostasis
• mitochondrial calcium ion transmembrane transport
• modulation of excitatory postsynaptic potential
• monoatomic ion transport
• myelination
• negative regulation of intracellular signal transduction
• oligodendrocyte differentiation
• regulation of cardiac conduction
• regulation of skeletal muscle contraction
• sodium ion transmembrane transport
• synapse organization
• telencephalon development

Molecular functions

• calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
• calcium:sodium antiporter activity
• calmodulin binding
• metal ion binding

Cellular components

• acrosomal vesicle
• anchoring junction
• axon
• axon terminus
• centrosome
• cytosol
• dendrite
• dendritic spine
• endoplasmic reticulum membrane
• microtubule
• microtubule cytoskeleton
• mitochondrial outer membrane
• neuromuscular junction
• neuronal cell body
• nucleoplasm
• perikaryon
• perinuclear region of cytoplasm
• plasma membrane
• postsynapse
• postsynaptic density
• postsynaptic membrane
• sarcolemma
• sarcoplasm
• sperm end piece
• synapse

Protein domainsUniProt · Pfam · InterPro

• Na-Ca exchanger/integrin-beta4
• Sodium/calcium exchanger protein
• Sodium/calcium exchanger membrane region
• Sodium/calcium exchanger domain, C-terminal extension
• CalX-like domain superfamily
• NCX, central ion-binding domain superfamily
• Calcium/Cation Antiporter
• Sodium/calcium exchanger protein
• Calx-beta domain
• C-terminal extension of sodium/calcium exchanger domain

KeywordsUniProt

• Antiport
• Calcium
• Calcium transport
• Calmodulin-binding
• Cell junction
• Cell membrane
• Cell projection
• Cytoplasm
• Endoplasmic reticulum
• Glycoprotein
• Ion transport
• Membrane
• Metal-binding
• Mitochondrion
• Mitochondrion outer membrane
• Repeat
• Signal
• Sodium
• Sodium transport
• Synapse
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of SLC8A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AKAP1