Seroatlas · Human Serome Atlas

CCDC102A

Coiled-coil domain-containing protein 102A

Also known as: C102A_HUMAN, MGC10992

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A19
Gene: CCDC102A
Ensembl: ENSG00000135736
Chromosome: 16
Canonical length: 550 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to be part of myosin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q96A19|CCDC102A
     1  MSHGPSPRLA ESPQLSKGSL LTILGSPSPE RMGPADSLPP TPPSGTPSPG PPPALPLPPA
    61  PALLADGDWE SREELRLREL EEARARAAQM EKTMRRWSDC TANWREKWSK VRAERNRARE
   121  EVRQLRQRLD ALTKELAGAR RERQEAQGEC EARGRELARL RGARGVADQT RDGPEPEAER
   181  EPVRDVGSER PPGSQELELV ESLLKSMPEE SEDCWEARSL GAGGPRGSSG RQERSRLPWE
   241  DTAATEEEAS KLTALRLRLD ESQKVLLKER EDKLALSRNI EKLEGELSQW KIKYEELSKT
   301  KQEMLKQLSI LKEAHQDELG RMSEDLEDEL GARSSMDRKM AELRGEMERL QAENAAEWGR
   361  RERLETEKLG LERENKKLRA QVGDLEEALA RRRRQTASAL DCDLRASQAA LFEKNKELAD
   421  LKHVHGKLKK QFQEKVAELA HANRRVEQHE AEVKKLRLRV EELKKELAQA EDELDEAHNQ
   481  ARKLQRSLDE QTEQSENLQV QLEHLQSRLR RQQQNAPLFG KIRSARFGTE EAEDGTSDLD
   541  EDEDLQIQVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC102A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 15 nTPM
urinary bladder: 12 nTPM
endometrium: 11 nTPM
cervix: 11 nTPM
colon: 11 nTPM
fallopian tube: 10 nTPM

Single-cell type

peritubular myoid cells: 33 nCPM
smooth muscle cells: 27 nCPM
breast myoepithelial cells: 26 nCPM
respiratory ciliated cells: 25 nCPM
epididymal efferent duct ciliated cells: 20 nCPM
vascular smooth muscle cells: 18 nCPM

Immune cell

memory CD8 T-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM
MAIT T-cell: 0.9 nTPM
memory B-cell: 0.9 nTPM
naive CD8 T-cell: 0.8 nTPM
NK-cell: 0.6 nTPM

Brain region

choroid plexus: 7.5 nTPM
midbrain: 3.9 nTPM
medulla oblongata: 3.8 nTPM
thalamus: 3.6 nTPM
spinal cord: 3.2 nTPM
pons: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

myosin complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC102A as an antibody target. Whether an autoantibody or antibody against CCDC102A could matter depends on whether native CCDC102A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC102A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC102A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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