Seroatlas · Human Serome Atlas

MYH16

Putative uncharacterized protein MYH16

Also known as: MYH16_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6N6
Gene
MYH16
Canonical length
1097 aa

OverviewNCBI Gene

No narrative summary is available for MYH16 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1097 residues, UniProt reviewed canonical sequence.

>Q9H6N6|MYH16
     1  MGLKVIQQNV HKFLQLRFWG WWKLYNKVKP LLNVARQEEE MKAKEEELRK AMAQTQELVN
    61  KVKELEEKTA TLSQEKNDLT IQLQAEQENL MDAEERLTWM MKTKMDLESQ ISDMRERLEE
   121  EEGMAASLSA AKRKLEGELS DLKRDLEGLE TTLAKTEKEK QALDHKVRTL TGDLSLREDS
   181  ITKLQKEKRA LEELHQKTLD DLQAEEDKVN HLTKNNSKLS TQIHELEDNW EQEKKIRAEV
   241  EKARRKAESD LKMTIDNLNE MERSKLDLEE VVKKRDLEIN SVNSKYEDEQ SLNSTLQRKL
   301  KEHQDRIEEL EEELEAERAM RAKIEQNRKR EAELLKLRRE LEEAALQSEA TASTLRKKHV
   361  DSMAELTEHV ESLQRVKSKL EKDKQVMKAE IDDLNASMET IQKSKMNAEA HVRKLEDSLS
   421  EANAKVAELE RNQAEINAIR TRLQAENSEL SREYEESQSR LNQILRIKTS LTSQVDDYKR
   481  QLDEESKSRS TAVVSLANTK HDLDLVKEQL EEEQGGKSEL QRLVSKLNTE VTTWRTKYET
   541  DAIQRTEELE ETKRKLAARL QEAEEAAETA QARAASLEKN KQRLQAEVED LTIDLEKANA
   601  AAAALDKKQR LFDKMLAEWQ QKCEELQVEV DSSQKECRMY MTESFKIKTA YEESLEHLES
   661  VKKENKTLQE EIKDLIDQLG EGGRSVHELQ KLKKKLEMEK EELQVALEEA ESSLEVEESK
   721  VIRIQLELAQ VKADIDRRIH EKEEEFEATR KNHQRAIESL QASLEAEAKG RAEALRLKKK
   781  METDLNEMEI QLDHANKNNS ELVKTLKRLQ QQIKDLQVQM DEDARQHEEL RKQYNLQERR
   841  LSLLQTELEE VRSALEGSER SRKLLEQEVV EITEWHNEIN IQNQSLLVVK RKLESDVQRI
   901  SNEHEELISE FRLTEERAKK AMMDAARMAE ELRQEQDHCM HLEKIKKNYE VTIKDLQAKM
   961  EEAEQLALKG GKRTIMKLEA RIKELETELD GEQKQHVETV KTLCKNERRL KELVFQTEED
  1021  HKTNQRMQAL VEKLQNKLKV YKRQIEEAED QANQTLARYR KTVHELDDAE DRAGMAETAL
  1081  NKLRTRHRVA GKGITSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYH16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYH16 as an antibody target. Whether an autoantibody or antibody against MYH16 could matter depends on whether native MYH16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYH16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYH16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYH16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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