Phosphoribosyltransferase domain
IPR000836
Definition
This entry refers to the phosphoribosyl transferase (PRT) type I domain. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrpphosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. This domain is found in a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase [ec:2.4.2.7], hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase [ec:2.4.2.8], ribose-phosphate pyrophosphokinase [ec:2.7.6.1], amidophosphoribosyltransferase [ec:2.4.2.14], orotate phosphoribosyltransferase [ec:2.4.2.10], uracil phosphoribosyltransferase [ec:2.4.2.9], and xanthine-guanine phosphoribosyltransferase [ec:2.4.2.22]. In Arabidopsis, at the very N terminus of this domain is the P-Loop NTPase domain [[cite:PMID:17143579], [cite:PMID:11751055], [cite:PMID:18550080], [cite:PMID:15689504], [cite:PMID:18399692], [cite:PMID:12808089], [cite:PMID:8894695], [cite:PMID:22075667], [cite:PMID:15096496], [cite:PMID:7030616], [cite:PMID:6105839], [cite:PMID:21366534], [cite:PMID:18535147]].
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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