Seroatlas · Human Serome Atlas

PRPSAP2

Phosphoribosyl pyrophosphate synthase-associated protein 2

Also known as: KPRB_HUMAN, PAP41

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60256
Gene
PRPSAP2
Ensembl
ENSG00000141127
Chromosome
17
Canonical length
369 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>O60256|PRPSAP2
     1  MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR
    61  VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR
   121  KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY
   181  RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS
   241  LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
   301  LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY
   361  LFRNIGLDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRPSAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 54 nTPM
  • lymph node: 48 nTPM
  • retina: 43 nTPM
  • cerebellum: 37 nTPM
  • spinal cord: 36 nTPM
  • testis: 30 nTPM

Single-cell type

  • plasma cells: 90 nCPM
  • late spermatids: 87 nCPM
  • differentiating spermatogonia: 87 nCPM
  • proximal tubule cells: 80 nCPM
  • late primary spermatocytes: 77 nCPM
  • rod photoreceptor cells: 71 nCPM

Immune cell

  • naive CD4 T-cell: 46 nTPM
  • memory B-cell: 44 nTPM
  • naive B-cell: 40 nTPM
  • NK-cell: 37 nTPM
  • T-reg: 36 nTPM
  • naive CD8 T-cell: 35 nTPM

Brain region

  • cerebellum: 78 nTPM
  • white matter: 73 nTPM
  • medulla oblongata: 56 nTPM
  • spinal cord: 53 nTPM
  • hypothalamus: 51 nTPM
  • hippocampal formation: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
2.6
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRPSAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRPSAP2 as an antibody target. Whether an autoantibody or antibody against PRPSAP2 could matter depends on whether native PRPSAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRPSAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRPSAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRPSAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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