Seroatlas · Human Serome Atlas

PRTFDC1

Phosphoribosyltransferase domain-containing protein 1

Also known as: HHGP, PRDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRG1
Gene: PRTFDC1
Ensembl: ENSG00000099256
Chromosome: 10
Canonical length: 225 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein homodimerization activity. Predicted to be involved in purine ribonucleoside salvage. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q9NRG1|PRTFDC1
     1  MAGSSEEAPD YGRGVVIMDD WPGYDLNLFT YPQHYYGDLE YVLIPHGIIV DRIERLAKDI
    61  MKDIGYSDIM VLCVLKGGYK FCADLVEHLK NISRNSDRFV SMKVDFIRLK SYRNDQSMGE
   121  MQIIGGDDLS TLAGKNVLIV EDVVGTGRTM KALLSNIEKY KPNMIKVASL LVKRTSRSDG
   181  FRPDYAGFEI PNLFVVGYAL DYNEYFRDLN HICVINEHGK EKYRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRTFDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 34 nTPM
midbrain: 28 nTPM
basal ganglia: 26 nTPM
cerebral cortex: 26 nTPM
amygdala: 25 nTPM
ovary: 24 nTPM

Single-cell type

astrocytes: 140 nCPM
oligodendrocytes: 140 nCPM
bergmann glia: 134 nCPM
ependymal cells: 127 nCPM
platelets: 108 nCPM
oligodendrocyte progenitor cells: 105 nCPM

Immune cell

NK-cell: 4.5 nTPM
total PBMC: 0.9 nTPM
MAIT T-cell: 0.5 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

white matter: 61 nTPM
basal ganglia: 44 nTPM
medulla oblongata: 43 nTPM
spinal cord: 39 nTPM
hypothalamus: 37 nTPM
cerebellum: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

purine ribonucleoside salvage

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRTFDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HPRT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRTFDC1 as an antibody target. Whether an autoantibody or antibody against PRTFDC1 could matter depends on whether native PRTFDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRTFDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRTFDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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