Seroatlas · Human Serome Atlas

UPRT

Uracil phosphoribosyltransferase homolog

Also known as: DKFZp781E1243, FUR1, MGC23937, RP11-311P8.3, UPP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BW1
Gene: UPRT
Ensembl: ENSG00000094841
Chromosome: X
Canonical length: 309 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q96BW1|UPRT
     1  MATELQCPDS MPCHNQQVNS ASTPSPEQLR PGDLILDHAG GNRASRAKVI LLTGYAHSSL
    61  PAELDSGACG GSSLNSEGNS GSGDSSSYDA PAGNSFLEDC ELSRQIGAQL KLLPMNDQIR
   121  ELQTIIRDKT ASRGDFMFSA DRLIRLVVEE GLNQLPYKEC MVTTPTGYKY EGVKFEKGNC
   181  GVSIMRSGEA MEQGLRDCCR SIRIGKILIQ SDEETQRAKV YYAKFPPDIY RRKVLLMYPI
   241  LSTGNTVIEA VKVLIEHGVQ PSVIILLSLF STPHGAKSII QEFPEITILT TEVHPVAPTH
   301  FGQKYFGTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UPRT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
bone marrow: 13 nTPM
kidney: 11 nTPM
adrenal gland: 10 nTPM
duodenum: 10 nTPM
tongue: 10 nTPM

Single-cell type

esophageal apical cells: 105 nCPM
parietal cells: 57 nCPM
megakaryocytes: 43 nCPM
choroid plexus epithelial cells: 42 nCPM
somatotrophs: 40 nCPM
epicardial cells: 39 nCPM

Immune cell

non-classical monocyte: 18 nTPM
NK-cell: 15 nTPM
T-reg: 14 nTPM
myeloid DC: 11 nTPM
intermediate monocyte: 11 nTPM
naive CD4 T-cell: 9.4 nTPM

Brain region

midbrain: 12 nTPM
hypothalamus: 12 nTPM
choroid plexus: 12 nTPM
pons: 11 nTPM
white matter: 11 nTPM
cerebral cortex: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.58
gnomAD missense Z: 1.45
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UPRT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UCKL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UPRT as an antibody target. Whether an autoantibody or antibody against UPRT could matter depends on whether native UPRT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UPRT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UPRT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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