Triacylglycerol lipase family
IPR000734
Definition
Triglyceride lipases ([ec:3.1.1.3]) are lipolytic enzymes that hydrolyse ester linkages of triglycerides PMID:3147715. Lipases are widely distributed in animals, plants and prokaryotes. At least three tissue-specific isozymes exist in higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase ([ec:3.1.1.34]), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL) PMID:2917565. The most conserved region in all these proteins is centred around a serine residue which has been shown PMID:2304545 to participate, with an histidine and an aspartic acid residue, in a charge relay system. Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase ([ec:2.3.1.43]) (LCAT) PMID:3458198, which catalyses fatty acid transfer between phosphatidylcholine and cholesterol.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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