LIPI
Lipase member I
Also known as: CT17, LIPI_HUMAN, LPDL, mPA-PLA1beta, PLA1C, PRED5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6XZB0
- Gene
- LIPI
- Ensembl
- ENSG00000188992
- Chromosome
- 21
- Canonical length
- 460 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Plasma membrane
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Canonical amino-acid sequenceUniProt
460 residues, UniProt reviewed canonical sequence.
>Q6XZB0|LIPI
1 MRVYIFLCLM CWVRSDNKRP CLEFSQLSVK DSFRDLFIPR IETILMMYTR NNLNCAEPLF
61 EQNNSLNVNF NTQKKTVWLI HGYRPVGSIP LWLQNFVRIL LNEEDMNVIV VDWSRGATTF
121 IYNRAVKNTR KVAVSLSVHI KNLLKHGASL DNFHFIGVSL GAHISGFVGK IFHGQLGRIT
181 GLDPAGPRFS RKPPYSRLDY TDAKFVDVIH SDSNGLGIQE PLGHIDFYPN GGNKQPGCPK
241 SIFSGIQFIK CNHQRAVHLF MASLETNCNF ISFPCRSYKD YKTSLCVDCD CFKEKSCPRL
301 GYQAKLFKGV LKERMEGRPL RTTVFLDTSG TYPFCTYYFV LSIIVPDKTM MDGSFSFKLL
361 NQLGMIEEPR LYEKNKPFYK LQEVKILAQF YNDFVNISSI GLTYFQSSNL QCSTCTYKIQ
421 SLMLKSLTYP ERPPLCRYNI VLKDREEVFL NPNTCTPKNTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LIPI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 396 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 396 nTPM
- thyroid gland: 2.3 nTPM
- pancreas: 0.1 nTPM
- retina: 0.1 nTPM
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
Single-cell type
- epididymal principal cells: 497 nCPM
- fibro-adipogenic progenitors: 51 nCPM
- endometrial stromal cells: 29 nCPM
- adipocytes: 14 nCPM
- epicardial cells: 14 nCPM
- smooth muscle cells: 11 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.6 nTPM
- cerebellum: 0.4 nTPM
- pons: 0.4 nTPM
- white matter: 0.4 nTPM
- basal ganglia: 0.3 nTPM
- hippocampal formation: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.37
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LIPI as an antibody target. Whether an autoantibody or antibody against LIPI could matter depends on whether native LIPI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LIPI is annotated at the cell surface, where native LIPI is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LIPI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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