Seroatlas · Human Serome Atlas

PLA1A

Phospholipase A1 member A

Also known as: PLA1A_HUMAN, ps-PLA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53H76
Gene: PLA1A
Ensembl: ENSG00000144837
Chromosome: 3
Canonical length: 456 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q53H76|PLA1A
     1  MPPGPWESCF WVGGLILWLS VGSSGDAPPT PQPKCADFQS ANLFEGTDLK VQFLLFVPSN
    61  PSCGQLVEGS SDLQNSGFNA TLGTKLIIHG FRVLGTKPSW IDTFIRTLLR ATNANVIAVD
   121  WIYGSTGVYF SAVKNVIKLS LEISLFLNKL LVLGVSESSI HIIGVSLGAH VGGMVGQLFG
   181  GQLGQITGLD PAGPEYTRAS VEERLDAGDA LFVEAIHTDT DNLGIRIPVG HVDYFVNGGQ
   241  DQPGCPTFFY AGYSYLICDH MRAVHLYISA LENSCPLMAF PCASYKAFLA GRCLDCFNPF
   301  LLSCPRIGLV EQGGVKIEPL PKEVKVYLLT TSSAPYCMHH SLVEFHLKEL RNKDTNIEVT
   361  FLSSNITSSS KITIPKQQRY GKGIIAHATP QCQINQVKFK FQSSNRVWKK DRTTIIGKFC
   421  TALLPVNDRE KMVCLPEPVN LQASVTVSCD LKIACV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

epididymis: 131 nTPM
choroid plexus: 86 nTPM
seminal vesicle: 63 nTPM
parathyroid gland: 62 nTPM
liver: 37 nTPM
lung: 21 nTPM

Single-cell type

epididymal principal cells: 102 nCPM
epididymal efferent duct absorptive cells: 92 nCPM
thymic myoid cells: 82 nCPM
choroid plexus epithelial cells: 58 nCPM
hepatocytes: 38 nCPM
retinal pigment epithelial cells: 30 nCPM

Immune cell

T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 34 nTPM
thalamus: 12 nTPM
spinal cord: 8.9 nTPM
pons: 8.6 nTPM
medulla oblongata: 8.5 nTPM
hippocampal formation: 7.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLA1A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Familial hypercholesterolemia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA1A as an antibody target. Whether an autoantibody or antibody against PLA1A could matter depends on whether native PLA1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA1A is annotated as secreted, so native PLA1A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLA1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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