Seroatlas · Human Serome Atlas

TSPYL2

Testis-specific Y-encoded-like protein 2

Also known as: CDA1, CINAP, CTCL, DENTT, HRIHFB2216, SE20-4, TSPX, TSYL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2G4
Gene: TSPYL2
Ensembl: ENSG00000184205
Chromosome: X
Canonical length: 693 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

693 residues, UniProt reviewed canonical sequence.

>Q9H2G4|TSPYL2
     1  MDRPDEGPPA KTRRLSSSES PQRDPPPPPP PPPLLRLPLP PPQQRPRLQE ETEAAQVLAD
    61  MRGVGLGPAL PPPPPYVILE EGGIRAYFTL GAECPGWDST IESGYGEAPP PTESLEALPT
   121  PEASGGSLEI DFQVVQSSSF GGEGALETCS AVGWAPQRLV DPKSKEEAII IVEDEDEDER
   181  ESMRSSRRRR RRRRRKQRKV KRESRERNAE RMESILQALE DIQLDLEAVN IKAGKAFLRL
   241  KRKFIQMRRP FLERRDLIIQ HIPGFWVKAF LNHPRISILI NRRDEDIFRY LTNLQVQDLR
   301  HISMGYKMKL YFQTNPYFTN MVIVKEFQRN RSGRLVSHST PIRWHRGQEP QARRHGNQDA
   361  SHSFFSWFSN HSLPEADRIA EIIKNDLWVN PLRYYLRERG SRIKRKKQEM KKRKTRGRCE
   421  VVIMEDAPDY YAVEDIFSEI SDIDETIHDI KISDFMETTD YFETTDNEIT DINENICDSE
   481  NPDHNEVPNN ETTDNNESAD DHETTDNNES ADDNNENPED NNKNTDDNEE NPNNNENTYG
   541  NNFFKGGFWG SHGNNQDSSD SDNEADEASD DEDNDGNEGD NEGSDDDGNE GDNEGSDDDD
   601  RDIEYYEKVI EDFDKDQADY EDVIEIISDE SVEEEGIEEG IQQDEDIYEE GNYEEEGSED
   661  VWEEGEDSDD SDLEDVLQVP NGWANPGKRG KTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPYL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 341 nTPM

Expression across tissuesHPA

Tissue

ovary: 341 nTPM
cerebellum: 296 nTPM
pituitary gland: 295 nTPM
basal ganglia: 214 nTPM
cerebral cortex: 191 nTPM
blood vessel: 169 nTPM

Single-cell type

ovarian stromal cells: 346 nCPM
t-cells: 325 nCPM
pdcs: 242 nCPM
innate lymphoid cells: 230 nCPM
mast cells: 225 nCPM
epididymal principal cells: 194 nCPM

Immune cell

plasmacytoid DC: 15 nTPM
naive CD4 T-cell: 14 nTPM
memory CD4 T-cell: 11 nTPM
naive CD8 T-cell: 10 nTPM
MAIT T-cell: 9.3 nTPM
T-reg: 8.4 nTPM

Brain region

hypothalamus: 197 nTPM
cerebral cortex: 193 nTPM
basal ganglia: 151 nTPM
cerebellum: 133 nTPM
hippocampal formation: 131 nTPM
amygdala: 129 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.87
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPYL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPYL2 as an antibody target. Whether an autoantibody or antibody against TSPYL2 could matter depends on whether native TSPYL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPYL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSPYL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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