Seroatlas · Human Serome Atlas

YJU2B

Probable splicing factor YJU2B

Also known as: CCDC130, MGC10471, YJU2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P13994
Gene: YJU2B
Ensembl: ENSG00000104957
Chromosome: 19
Canonical length: 396 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in response to virus. Predicted to be located in nucleus. Predicted to be part of U2-type spliceosomal complex and post-mRNA release spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>P13994|YJU2B
     1  MGERKGVNKY YPPDFNPEKH GSLNRYHNSH PLRERARKLS QGILIIRFEM PYNIWCDGCK
    61  NHIGMGVRYN AEKKKVGNYY TTPIYRFRMK CHLCVNYIEM QTDPANCDYV IVSGAQRKEE
   121  RWDMADNEQV LTTEHEKKQK LETDAMFRLE HGEADRSTLK KALPTLSHIQ EAQSAWKDDF
   181  ALNSMLRRRF REKKKAIQEE EERDQALQAK ASLTIPLVPE TEDDRKLAAL LKFHTLDSYE
   241  DKQKLKRTEI ISRSWFPSAP GSASSSKVSG VLKKLAQSRR TALATSPITV GDLGIVRRRS
   301  RDVPESPQHA ADTPKSGEPR VPEEAAQDRP MSPGDCPPET TETPKCSSPR GQEGSRQDKP
   361  LSPAGSSQEA ADTPDTRHPC SLGSSLVADY SDSESE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YJU2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

ovary: 42 nTPM
thyroid gland: 36 nTPM
spleen: 36 nTPM
small intestine: 33 nTPM
pituitary gland: 33 nTPM
cervix: 33 nTPM

Single-cell type

late primary spermatocytes: 74 nCPM
oocytes: 74 nCPM
ependymal cells: 59 nCPM
choroid plexus epithelial cells: 55 nCPM
distal convoluted tubule cells: 54 nCPM
proximal tubule cells: 54 nCPM

Immune cell

eosinophil: 20 nTPM
basophil: 18 nTPM
naive B-cell: 18 nTPM
MAIT T-cell: 16 nTPM
memory B-cell: 15 nTPM
non-classical monocyte: 15 nTPM

Brain region

white matter: 51 nTPM
cerebral cortex: 43 nTPM
medulla oblongata: 42 nTPM
pons: 40 nTPM
choroid plexus: 39 nTPM
thalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
DepMap mean gene effect: -0.57
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YJU2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF165

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YJU2B as an antibody target. Whether an autoantibody or antibody against YJU2B could matter depends on whether native YJU2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YJU2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YJU2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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